Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ACP3 | P15309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2192405 | 0.99 | ALDH1A1 (0.47) | ALDH1A1KDM4EGAAMAPTPOLB | |
| SCHEMBL1009960 | 0.82 | KDM4E (0.42) | ALDH1A1KDM4EMAPTLMNAHTT | |
| Bromide SCHEMBL2191910 | 0.81 | KDM4E (0.41) | ALDH1A1KDM4EMAPTLMNAHTT | |
| SCHEMBL20138573 | 0.79 | CYP11B1 (0.53) | ALDH1A1KDM4EMAPTPOLBTP53 | |
| Hydrochloric Acid SCHEMBL2012582 | 0.78 | CYP11B1 (0.55) | ALDH1A1KDM4EMAPTPOLBTP53 | |
| Water SCHEMBL18260003 | 0.78 | CYP11B1 (0.51) | ALDH1A1KDM4EMAPTPOLBTP53 | |
| SCHEMBL28907511 | 0.77 | PON1 (0.32) | MAPTHTTSMN1; SMN2 | |
| SCHEMBL667065 | 0.76 | PON1 (0.50) | MAPTPOLBLMNAHTTL3MBTL1 | |
| SCHEMBL1011073 | 0.75 | LPO (0.56) | ALDH1A1KDM4EMAPTLMNATP53 | |
| SCHEMBL31238837 | 0.75 | PON1 (0.47) | MAPTPOLBLMNAHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268652-B1 | PLATINUM-N-HETEROCYCLIC CARBENE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2012-12-19 | — | — | EP | disclosed |
| EP-2268652-A2 | PLATINUM-N-HETEROCYCLIC CARBENE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009118475-A2 | PLATINUM-N-HETEROCYCLIC CARBENE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-10-01 | — | — | WO | disclosed |