Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 11/20 | 0.81 |
| ▸ | TRPC6 | Q9Y210 | 11/20 | 0.81 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.44 |
| ▸ | CTRC | Q99895 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL789898 | 0.92 | TRPC3 (0.75) | TRPC3TRPC6NPC1ALDH1A1HPGD | |
| SCHEMBL10087863 | 0.80 | TRPC3 (0.58) | TRPC3TRPC6ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL806598 | 0.77 | TRPC3 (0.74) | TRPC3TRPC6NPC1ALDH1A1HPGD | |
| SCHEMBL789564 | 0.77 | TRPC3 (1.00) | TRPC3TRPC6L3MBTL1GAAMAPT | |
| SCHEMBL789091 | 0.76 | TRPC3 (0.78) | TRPC3TRPC6NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL790396 | 0.75 | TRPC3 (0.77) | TRPC3TRPC6NPC1ALDH1A1HPGD | |
| SCHEMBL21708015 | 0.73 | MAPT (0.67) | NPC1ALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL806645 | 0.72 | TRPC3 (0.58) | TRPC3TRPC6ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL13450334 | 0.72 | THRB (0.63) | ALDH1A1SMN1; SMN2L3MBTL1MAPTKMT2A | |
| SCHEMBL22840323 | 0.71 | NPC1 (0.50) | TRPC3TRPC6NPC1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037351-A1 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012037351-A1 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |