Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 9/20 | 0.74 |
| ▸ | TRPC6 | Q9Y210 | 9/20 | 0.74 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | CCR4 | P51679 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL789898 | 0.77 | TRPC3 (0.75) | TRPC3TRPC6NPC1RAB9AALDH1A1 | |
| SCHEMBL10087864 | 0.77 | TRPC3 (0.81) | TRPC3TRPC6NPC1RAB9AALDH1A1 | |
| SCHEMBL789564 | 0.77 | TRPC3 (1.00) | TRPC3TRPC6L3MBTL1GAAMAPT | |
| SCHEMBL790396 | 0.75 | TRPC3 (0.77) | TRPC3TRPC6NPC1RAB9AALDH1A1 | |
| SCHEMBL789091 | 0.73 | TRPC3 (0.78) | TRPC3TRPC6NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL789085 | 0.71 | NPC1 (0.98) | TRPC3TRPC6NPC1RAB9AALDH1A1 | |
| SCHEMBL1704212 | 0.69 | KMT2A (0.57) | TRPC3TRPC6NPC1RAB9AALDH1A1 | |
| SCHEMBL798510 | 0.67 | TRPC3 (0.67) | TRPC3TRPC6NPC1RAB9AALDH1A1 | |
| SCHEMBL15014648 | 0.66 | TRPC3 (0.54) | TRPC3TRPC6NPC1RAB9AALDH1A1 | |
| SCHEMBL13744784 | 0.66 | L3MBTL1 (0.73) | TRPC3TRPC6NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037351-A1 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |