Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.47 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15070505 | 0.84 | ALDH1A1 (0.51) | NPC1RAB9AHPGDSMN1; SMN2ACHE | |
| SCHEMBL13744784 | 0.78 | L3MBTL1 (0.73) | NPC1RAB9AHPGDSMN1; SMN2ACHE | |
| SCHEMBL30484494 | 0.77 | ALDH1A1 (0.51) | NPC1RAB9AHPGDSMN1; SMN2ACHE | |
| SCHEMBL17546317 | 0.75 | CYP3A4 (0.53) | HPGDACHEALDH1A1APOBEC3AAPOBEC3G | |
| SCHEMBL13450341 | 0.74 | SMN1; SMN2 (0.61) | HPGDSMN1; SMN2ACHEKDM4EHSD11B1 | |
| SCHEMBL17546311 | 0.74 | ACHE (0.50) | NPC1RAB9AHPGDSMN1; SMN2ACHE | |
| SCHEMBL13504099 | 0.74 | SMN1; SMN2 (0.68) | NPC1RAB9AHPGDSMN1; SMN2ACHE | |
| SCHEMBL12753374 | 0.73 | HSD11B1 (0.60) | NPC1RAB9AHPGDSMN1; SMN2THRB | |
| SCHEMBL13450575 | 0.72 | HSD11B1 (0.60) | NPC1RAB9AHPGDSMN1; SMN2ACHE | |
| SCHEMBL22972377 | 0.72 | SMYD3 (0.49) | NPC1RAB9AHPGDL3MBTL1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3535267-B1 | [1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PDE2 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-30 | — | — | EP | disclosed |