SCHEMBL10089941

SCHEMBL10089941

Cc1cc(C#N)cc(C(=O)NCc2cccc(OC(F)(F)F)c2)c1NC(=O)c1cc(Cn2nnc(C(F)(F)F)n2)nn1-c1ncccc1Cl

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
RIPK1 Q13546 5/20 0.37
GLS O94925 5/20 0.36
GPR6 P46095 1/20 0.36
ABCB1 P08183 1/20 0.35
PPARG P37231 2/20 0.35
ROCK2 O75116 1/20 0.35
ROCK1 Q13464 1/20 0.35
SLC16A3 O15427 1/20 0.35
SLC16A1 P53985 1/20 0.35
MCTS1 Q9ULC4 1/20 0.35
CNR1 P21554 3/20 0.34
PPARD Q03181 1/20 0.34
PPARA Q07869 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10090042 0.95 GPR6 (0.35) RIPK1GPR6
SCHEMBL10090035 0.94 SLC2A1 (0.36) GPR6
SCHEMBL10089944 0.93 RIPK1 (0.38) RIPK1GLSABCB1PPARGROCK2
SCHEMBL10089953 0.93 RIPK1 (0.37) RIPK1GLSABCB1PPARGROCK2
SCHEMBL10090019 0.92 RIPK1 (0.38) RIPK1GLSABCB1PPARGROCK2
SCHEMBL10090032 0.92 GPR6 (0.36) RIPK1GLSGPR6ABCB1ROCK2
SCHEMBL10089907 0.92 ABCB1 (0.37) RIPK1GLSABCB1PPARGCNR1
SCHEMBL10089861 0.92 RIPK1 (0.39) RIPK1GLSABCB1PPARGROCK2
SCHEMBL10089933 0.92 SLC2A1 (0.37)
SCHEMBL10089887 0.90 SLC2A1 (0.34) PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8791143-B2 Anthranilic diamide derivatives having cyclic side-chains BAYER CROPSCIENCE AG (DE) 2014-07-29 US disclosed
US-20120010249-A1 Anthranilic diamide derivatives having cyclic side-chains BAYER CROPSCIENCE AG (DE) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010249-A1 Anthranilic diamide derivatives having cyclic side-chains DDT, ADCY1, ANTXR2 RIPK1 4585/4885GLS 259/4885GPR6 2424/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.