SCHEMBL10089978

SCHEMBL10089978

Cc1cc(Cl)cc(C(=O)NCc2ccc(OC(F)F)cc2)c1NC(=O)c1cc(Cn2nnc(C(F)(F)F)n2)nn1-c1ncccc1Cl

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PPARG P37231 2/20 0.36
NR1I2 O75469 1/20 0.36
CPT1A P50416 1/20 0.34
CPT1B Q92523 1/20 0.34
MAPT P10636 1/20 0.32
LMNA P02545 1/20 0.32
POLB P06746 1/20 0.32
USP36 Q9P275 1/20 0.32
IDH1 O75874 1/20 0.32
ELANE P08246 5/20 0.32
GLS O94925 1/20 0.32
MMP13 P45452 1/20 0.32
DHODH Q02127 1/20 0.31
ALDH1A1 P00352 1/20 0.31
MT-CO2 P00403 1/20 0.31
CNR2 P34972 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10090026 0.95 PPARG (0.38) PPARGNR1I2CPT1ACPT1BMAPT
SCHEMBL10089916 0.95 KCNB1 (0.36) PPARGMMP13CNR2
SCHEMBL10089960 0.93 MMP13 (0.38) MAPTLMNAPOLBMMP13DHODH
SCHEMBL10089975 0.93 SLC2A1 (0.35) PPARGNR1I2CPT1ACPT1BIDH1
SCHEMBL10089898 0.93 PDE2A (0.35) PPARGLMNAALDH1A1
SCHEMBL10089892 0.92 DHODH (0.38) PPARGPOLBIDH1MMP13DHODH
SCHEMBL10089909 0.92 PPARG (0.36) PPARGNR1I2CPT1ACPT1BLMNA
SCHEMBL10089874 0.91 MMP13 (0.36) PPARGMAPTLMNAIDH1MMP13
SCHEMBL10089858 0.91 IDH1 (0.40) PPARGIDH1ELANEMMP13DHODH
SCHEMBL10089967 0.91 DHODH (0.36) PPARGLMNAIDH1MMP13DHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8791143-B2 Anthranilic diamide derivatives having cyclic side-chains BAYER CROPSCIENCE AG (DE) 2014-07-29 US disclosed
US-20120010249-A1 Anthranilic diamide derivatives having cyclic side-chains BAYER CROPSCIENCE AG (DE) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010249-A1 Anthranilic diamide derivatives having cyclic side-chains DDT, ADCY1, ANTXR2 PPARG 3227/4885NR1I2 2630/4885CPT1A 3152/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.