SCHEMBL10089909

SCHEMBL10089909

Cc1cc(Cl)cc(C(=O)NCc2ccc(OC(F)F)cc2)c1NC(=O)c1cc(Cn2nnc(C(F)F)n2)nn1-c1ncccc1Cl

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PPARG P37231 2/20 0.36
NR1I2 O75469 1/20 0.36
LMNA P02545 2/20 0.34
POLB P06746 1/20 0.34
CPT1A P50416 2/20 0.33
CPT1B Q92523 2/20 0.33
MMP13 P45452 2/20 0.32
GLS O94925 1/20 0.32
DHODH Q02127 1/20 0.32
ALDH1A1 P00352 1/20 0.32
MT-CO2 P00403 1/20 0.32
GPR6 P46095 1/20 0.32
RXFP1 Q9HBX9 1/20 0.31
CPT2 P23786 1/20 0.31
USP2 O75604 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10089977 0.94 KCNA5 (0.36) PPARGNR1I2MMP13GPR6
SCHEMBL10089932 0.93 GPR6 (0.36) PPARGNR1I2LMNAPOLBCPT1A
SCHEMBL10090044 0.93 PDE2A (0.35) PPARGALDH1A1SMN1; SMN2
SCHEMBL10089978 0.92 PPARG (0.36) PPARGNR1I2LMNAPOLBCPT1A
SCHEMBL10089844 0.90 MAPK8 (0.35) DHODHGPR6SMN1; SMN2
SCHEMBL10089922 0.89 ABCB1 (0.39) PPARGGLS
SCHEMBL13085289 0.88 ALDH1A1 (0.33) DHODHALDH1A1SMN1; SMN2
SCHEMBL13085131 0.88 DHODH (0.33) DHODHALDH1A1SMN1; SMN2
SCHEMBL10089881 0.88 GPR6 (0.36) PPARGNR1I2MMP13GLSGPR6
SCHEMBL13085332 0.87 DHODH (0.33) DHODHALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8791143-B2 Anthranilic diamide derivatives having cyclic side-chains BAYER CROPSCIENCE AG (DE) 2014-07-29 US disclosed
US-20120010249-A1 Anthranilic diamide derivatives having cyclic side-chains BAYER CROPSCIENCE AG (DE) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010249-A1 Anthranilic diamide derivatives having cyclic side-chains DDT, ADCY1, ANTXR2 PPARG 3227/4885NR1I2 2630/4885LMNA 2979/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.