Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.59 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.59 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.53 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.50 |
| ▸ | NEK1 | Q96PY6 | 4/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31418026 | 0.85 | CYP11B1 (0.59) | ATMCYP11B1CYP11B2CYP2A6GABRG2 | |
| SCHEMBL9008962 | 0.84 | CYP11B1 (0.61) | ATMCYP11B1CYP11B2CYP2A6GABRG2 | |
| SCHEMBL30285148 | 0.84 | CA12 (0.59) | GABRG2GABRB3GABRA5GABRA3CDK8 | |
| SCHEMBL7719381 | 0.84 | CA12 (0.59) | GABRG2GABRB3GABRA5GABRA3CDK8 | |
| SCHEMBL4592371 | 0.84 | CYP11B1 (0.58) | ATMCYP11B1CYP11B2CYP2A6GABRG2 | |
| SCHEMBL6436030 | 0.84 | CYP11B2 (0.58) | ATMCYP11B1CYP11B2CYP2A6GABRG2 | |
| SCHEMBL3715051 | 0.84 | ATM (0.69) | ATMCYP11B1CYP11B2CYP2A6GABRG2 | |
| SCHEMBL27266688 | 0.83 | DHODH (0.57) | MAPK14AAK1 | |
| SCHEMBL3714867 | 0.82 | ALDH1A1 (0.68) | ATMCYP11B1CYP11B2CYP2A6NEK1 | |
| SCHEMBL31705350 | 0.82 | ALDH1A1 (0.68) | ATMCYP11B1CYP11B2CYP2A6NEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367690-B2 | Aminopyridine derivatives having aurora a selective inhibitory action | VERTEX PHARMACEUTICALS INC. (US) | 2013-02-05 | — | — | US | disclosed |
| US-20120015969-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | BANYU PHARMACEUTICALS CO., LTD. (JP) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015969-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | AURKA, AURKC, AURKB | ATM 2231/4885CYP11B1 940/4885CYP11B2 924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.