Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.60 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.52 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.52 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 5/20 | 0.46 |
| ▸ | BCR | P11274 | 5/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | CTSC | P53634 | 1/20 | 0.45 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.45 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10094192 | 0.80 | DHODH (0.54) | DHODHALDH1A1NPC1POLBHPGD | |
| SCHEMBL22543353 | 0.79 | DHODH (0.62) | DHODHABL1BCREPHX2CTSC | |
| SCHEMBL10094191 | 0.78 | DHODH (0.51) | DHODHALDH1A1NPC1POLBHPGD | |
| SCHEMBL10094254 | 0.77 | RAB9A (0.54) | DHODHALDH1A1NPC1POLBHPGD | |
| SCHEMBL20553261 | 0.77 | HPGD (0.63) | DHODHABL1BCREPHX2CTSC | |
| SCHEMBL10094180 | 0.76 | NPC1 (0.47) | DHODHALDH1A1NPC1POLBHPGD | |
| SCHEMBL10094291 | 0.75 | CDC25B (0.51) | ALDH1A1NPC1POLBHPGDRAB9A | |
| SCHEMBL10094295 | 0.74 | ABCG2 (0.50) | — | |
| SCHEMBL10094260 | 0.74 | ADRA2A (0.45) | ALDH1A1NPC1POLBHPGDRAB9A | |
| SCHEMBL2739344 | 0.74 | LMNA (0.64) | DHODHTRPV1CTSCALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148535-B2 | Potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-04-03 | — | — | US | disclosed |
| US-8148535-B2 | Potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-04-03 | — | — | US | disclosed |
| US-20090233897-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-09-17 | — | — | US | disclosed |
| US-20090233897-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233897-A1 | Potassium Channel Inhibitors | KCNJ2, KCNQ2, KCNH2 | DHODH 1364/4885P2RY2 399/4885P2RY1 513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.