Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 7/20 | 0.40 |
| ▸ | CTSL | P07711 | 3/20 | 0.37 |
| ▸ | CTSB | P07858 | 3/20 | 0.37 |
| ▸ | CTSH | P09668 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1008660 | 1.00 | ZDHHC7 (0.42) | ZDHHC7CTSKCTSLCTSBCTSH | |
| SCHEMBL1008531 | 0.98 | CTSK (0.42) | ZDHHC7CTSKCTSLCTSBCTSH | |
| SCHEMBL1009204 | 0.96 | ZDHHC7 (0.42) | ZDHHC7CTSKCTSLCTSBCTSH | |
| SCHEMBL25762636 | 0.92 | ZDHHC7 (0.44) | ZDHHC7CTSKTSHRTHRB | |
| SCHEMBL11368057 | 0.92 | ZDHHC7 (0.44) | ZDHHC7CTSKTSHRTHRB | |
| SCHEMBL1008853 | 0.84 | ZDHHC7 (0.39) | ZDHHC7 | |
| SCHEMBL5560916 | 0.81 | METAP2 (0.41) | CTSKTSHRNPSR1THRB | |
| SCHEMBL16732113 | 0.80 | CTSK (0.41) | CTSKCTSLCTSBCTSHTSHR | |
| SCHEMBL22123618 | 0.79 | L3MBTL1 (0.37) | CTSKTSHRNPSR1 | |
| SCHEMBL1711658 | 0.78 | CTSK (0.41) | CTSKCTSLCTSBCTSHTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268633-A1 | PYRIDAZINONE GLUCOKINASE ACTIVATORS | F. Hoffmann-La Roche AG (CH) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009127544-A1 | PYRIDAZINONE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-10-22 | — | — | WO | disclosed |