Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | KIF11 | P52732 | 3/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | IKBKB | O14920 | 2/20 | 0.44 |
| ▸ | CHUK | O15111 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23479670 | 0.83 | BRD4 (0.53) | CA12CA1CA2CA9L3MBTL1 | |
| SCHEMBL28084837 | 0.80 | LMNA (0.49) | CA12CA1CA2CA9L3MBTL1 | |
| SCHEMBL10094416 | 0.79 | MAP2K4 (0.49) | L3MBTL1KIF11ALOX5PTGS2IKBKB | |
| SCHEMBL18853897 | 0.77 | IKBKB (0.49) | KEAP1KIF11KDM4EALDH1A1LMNA | |
| SCHEMBL10094332 | 0.77 | L3MBTL1 (0.74) | CA12CA1CA2CA9L3MBTL1 | |
| SCHEMBL29788170 | 0.77 | GRIA4 (0.55) | KEAP1KIF11PGRNR3C2ALOX5 | |
| SCHEMBL14450924 | 0.75 | MAPK10 (0.45) | NR3C2PTGS2ALDH1A1IKBKBCHUK | |
| SCHEMBL873846 | 0.75 | KEAP1 (0.75) | CA12CA1CA2CA9KEAP1 | |
| SCHEMBL10094319 | 0.74 | SMN1; SMN2 (0.56) | CA12CA1CA2CA9L3MBTL1 | |
| SCHEMBL31634174 | 0.74 | KDM1A (0.55) | KEAP1KIF11PGRNR3C2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148535-B2 | Potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-04-03 | — | — | US | disclosed |
| US-20090233897-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233897-A1 | Potassium Channel Inhibitors | KCNJ2, KCNQ2, KCNH2 | CA12 4614/4885CA1 3210/4885CA2 269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.