Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MIF | P14174 | 2/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8167408 | 1.00 | ALDH1A1 (0.52) | ALDH1A1TSHRTRPA1TDP1MIF | |
| SCHEMBL10814254 | 1.00 | ALDH1A1 (0.52) | ALDH1A1TSHRTRPA1TDP1MIF | |
| SCHEMBL8519566 | 0.85 | MEN1 (0.59) | ALDH1A1TRPA1TDP1MEN1KMT2A | |
| SCHEMBL17178869 | 0.81 | ALDH1A1 (0.52) | ALDH1A1TSHRTRPA1MIFCYP3A4 | |
| SCHEMBL19611522 | 0.81 | ALDH1A1 (0.52) | ALDH1A1TSHRTRPA1MIFCYP3A4 | |
| SCHEMBL15506263 | 0.81 | ALDH1A1 (0.52) | ALDH1A1TSHRTRPA1MIFCYP3A4 | |
| SCHEMBL21469244 | 0.78 | CYP1A2 (0.47) | ALDH1A1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL3547143 | 0.76 | ALDH1A1 (0.61) | ALDH1A1TSHRTRPA1TDP1MIF | |
| SCHEMBL253886 | 0.74 | ALDH1A1 (0.46) | ALDH1A1TSHRTRPA1MIFCYP3A4 | |
| SCHEMBL12198798 | 0.73 | ALDH1A1 (0.50) | ALDH1A1TSHRTRPA1TDP1CYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124778-B2 | Tricyclic inhibitors of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-02-28 | — | — | US | disclosed |
| US-20100216750-A1 | TRICYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216750-A1 | TRICYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | FADS1, FAAH, SCD | ALDH1A1 753/4885TSHR 1887/4885TRPA1 3790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.