SCHEMBL1009547

SCHEMBL1009547

N#CC(C#N)=Cc1ccc(N2CCOCC2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 10/20 1.00
MEN1 O00255 9/20 1.00
MAPT P10636 11/20 0.76
ALDH1A1 P00352 9/20 0.76
SMN1; SMN2 Q16637 5/20 0.76
LMNA P02545 4/20 0.65
NPC1 O15118 2/20 0.65
RAB9A P51151 2/20 0.65
THRB P10828 2/20 0.59
KDM4E B2RXH2 5/20 0.57
NPSR1 Q6W5P4 2/20 0.57
POLB P06746 1/20 0.57
CISD1 Q9NZ45 1/20 0.50
EGFR P00533 1/20 0.49
HTT P42858 2/20 0.46
CRHBP P24387 1/20 0.46
CRHR2 Q13324 1/20 0.46
TNNI3 P19429 1/20 0.46
TNNT2 P45379 1/20 0.46
TNNC1 P63316 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32675887 0.86 MEN1 (1.00) KMT2AMEN1MAPTALDH1A1SMN1; SMN2
SCHEMBL255364 0.85 MEN1 (0.97) KMT2AMEN1MAPTALDH1A1SMN1; SMN2
SCHEMBL255365 0.85 MEN1 (0.97) KMT2AMEN1MAPTALDH1A1SMN1; SMN2
SCHEMBL12554054 0.80 MEN1 (0.67) KMT2AMEN1MAPTALDH1A1SMN1; SMN2
SCHEMBL17120618 0.79 MEN1 (0.65) KMT2AMEN1MAPTALDH1A1SMN1; SMN2
SCHEMBL14968774 0.79 ALDH1A1 (1.00) KMT2AMEN1MAPTALDH1A1SMN1; SMN2
SCHEMBL14968775 0.79 ALDH1A1 (1.00) KMT2AMEN1MAPTALDH1A1SMN1; SMN2
SCHEMBL8724442 0.78 MEN1 (0.82) KMT2AMEN1MAPTALDH1A1SMN1; SMN2
SCHEMBL17120603 0.78 MEN1 (0.63) KMT2AMEN1MAPTALDH1A1SMN1; SMN2
SCHEMBL12306023 0.77 MEN1 (0.62) KMT2AMEN1MAPTALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4719245-A TRIMERIZATION CATALYST THE DOW CHEMICAL COMPANY (US) 1988-01-12 US claimed
US-10254562-B2 Methods for tailoring the refractive index of lenses BATTELLE MEMORIAL INSTITUTE (US) 2019-04-09 US disclosed
US-10254562-B2 Methods for tailoring the refractive index of lenses BATTELLE MEMORIAL INSTITUTE (US) 2019-04-09 US disclosed
US-10018853-B2 Methods of altering the refractive index of materials BATTELLE MEMORIAL INSTITUTE (US) 2018-07-10 US disclosed
US-10018853-B2 Methods of altering the refractive index of materials BATTELLE MEMORIAL INSTITUTE (US) 2018-07-10 US disclosed
US-9827088-B2 Methods of altering the refractive index of materials BATTELLE MEMORIAL INSTITUTE (US) 2017-11-28 US disclosed
US-9827088-B2 Methods of altering the refractive index of materials BATTELLE MEMORIAL INSTITUTE (US) 2017-11-28 US disclosed
US-9421090-B2 Adjustable intraocular lens BATTELLE MEDICAL INSTITUTE (US) 2016-08-23 US disclosed
US-9421090-B2 Adjustable intraocular lens BATTELLE MEDICAL INSTITUTE (US) 2016-08-23 US disclosed
US-20160229132-A1 METHODS OF ALTERING OPTICAL POWER OF A LENS BATTELLE MEMORIAL INSTITUTE 2016-08-11 US disclosed
US-20120268710-A1 ADJUSTABLE INTRAOCULAR LENS THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) 2012-10-25 US disclosed
US-20110144747-A1 ADJUSTABLE INTRAOCULAR LENS BATTELLE MEMORIAL INSTITUTE (US) 2011-06-16 US disclosed
US-20110144747-A1 ADJUSTABLE INTRAOCULAR LENS BATTELLE MEMORIAL INSTITUTE (US) 2011-06-16 US disclosed
EP-2268230-A1 ADJUSTABLE INTRAOCULAR LENS Battelle Memorial Institute (US) 2011-01-05 EP disclosed
WO-2009124231-A1 ADJUSTABLE INTRAOCULAR LENS BATTELLE MEMORIAL INSTITUTE (US) 2009-10-08 WO disclosed
WO-2009124231-A1 ADJUSTABLE INTRAOCULAR LENS BATTELLE MEMORIAL INSTITUTE (US) 2009-10-08 WO disclosed
US-4719245-A TRIMERIZATION CATALYST THE DOW CHEMICAL COMPANY (US) 1988-01-12 US disclosed
US-4703099-A CATALYTICALLY TRIMERIZING ISOCYANATES THE DOW CHEMICAL COMPANY (US) 1987-10-27 US disclosed
US-4632989-A KETENE AMINAL-OLEFIN REACTION PRODUCT AS CATALYSTS THE DOW CHEMICAL COMPANY (US) 1986-12-30 US disclosed
US-4536490-A REACTION PRODUCT OF KETENE-AMINAL AND UNSATURATED COMPOUND THE UPJOHN COMPANY (US) 1985-08-20 US disclosed