Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 3/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL707619 | 0.85 | ALOX5AP (0.56) | ALOX5APTRPV3 | |
| SCHEMBL13262159 | 0.78 | ALOX5AP (0.49) | ALOX5AP | |
| SCHEMBL14396912 | 0.74 | ALOX5AP (0.43) | ALOX5APESR1ESR2 | |
| SCHEMBL14397148 | 0.74 | ALOX5AP (0.43) | ALOX5APESR1ESR2 | |
| SCHEMBL705390 | 0.73 | ALOX5AP (0.43) | ALOX5APESR1ESR2 | |
| SCHEMBL708016 | 0.72 | ALOX5AP (0.73) | ALOX5AP | |
| SCHEMBL708015 | 0.72 | ALOX5AP (0.73) | ALOX5AP | |
| SCHEMBL14397218 | 0.72 | ALOX5AP (0.55) | ALOX5APTRPV3 | |
| SCHEMBL480207 | 0.71 | ALOX5AP (0.65) | ALOX5AP | |
| SCHEMBL480232 | 0.71 | ALOX5AP (0.65) | ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124628-B2 | Diaryl substituted alkanes | MERCK SHARP & DOHME CORP. (US) | 2012-02-28 | — | — | US | disclosed |
| US-20090258851-A1 | DIARYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258851-A1 | DIARYL SUBSTITUTED ALKANES | ALOX5, ALOX15, LTB4R2 | ALOX5AP 13/4885ESR1 2752/4885ESR2 940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.