Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | RAC1 | P63000 | 2/20 | 0.31 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.31 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10098970 | 0.84 | PDE3B (0.33) | CRHR1KDM4EPDE3BPDE3AGAA | |
| SCHEMBL10099062 | 0.77 | MAPT (0.34) | CRHR1KDM4EPDE3BPDE3AGAA | |
| SCHEMBL10098969 | 0.74 | P2RX3 (0.36) | PDE3BPDE3AGAAPDE4APDE4D | |
| SCHEMBL10099063 | 0.71 | CYP19A1 (0.40) | KDM4EPDE3BPDE3ASLC10A2RAC1 | |
| SCHEMBL10099094 | 0.70 | CXCL12 (0.40) | CRHR1KDM4EGAAHSP90AA1HSP90AB1 | |
| SCHEMBL23564604 | 0.70 | ELANE (0.45) | CRHR1KDM4EPDE3BPDE3AGAA | |
| SCHEMBL13913535 | 0.69 | ERN1 (0.41) | KDM4EPDE3BPDE3AGAAHSP90AA1 | |
| SCHEMBL172434 | 0.69 | KDM4E (0.47) | KDM4ESLC10A2ALDH1A1SMN1; SMN2 | |
| SCHEMBL19869248 | 0.67 | MAP3K14 (0.41) | CRHR1PDE3BPDE3AGAACXCL12 | |
| SCHEMBL17915875 | 0.67 | NOS3 (0.43) | KDM4ENOS3NOS1NOS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094897-A1 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094897-A1 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | EIF2AK2, HAVCR2, HDGF | CRHR1 2889/4885KDM4E 683/4885PDE3B 1284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.