Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 5/20 | 0.45 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | FNTB | P49356 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.38 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | QPCT | Q16769 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1010002 | 0.86 | QPCT (0.49) | CCR5PDE4DQPCT | |
| SCHEMBL1009113 | 0.85 | PDE4D (0.45) | PDE4DSLC16A3SLC16A1QPCT | |
| SCHEMBL1008443 | 0.85 | PDE4D (0.47) | PDE4D | |
| SCHEMBL1010197 | 0.84 | PDE4D (0.44) | PDE4DQPCT | |
| SCHEMBL1008929 | 0.81 | PDE4D (0.44) | PDE4DQPCT | |
| SCHEMBL1008748 | 0.80 | PDE4D (0.45) | PDE4DP2RX7QPCT | |
| SCHEMBL1008845 | 0.79 | PDE4D (0.44) | PDE4DQPCT | |
| SCHEMBL1009473 | 0.79 | PDE4D (0.42) | PDE4DPDK1 | |
| SCHEMBL1010050 | 0.79 | NR3C1 (0.50) | PDE4DQPCT | |
| SCHEMBL1011391 | 0.78 | L3MBTL1 (0.44) | PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268632-B1 | TERTIARY AMINE DERIVATIVES AS PHOSPHODIESTERASE-4 INHIBITORS | CHIESI FARMA SPA (IT) | 2012-08-08 | — | — | EP | claimed |
| EP-2268632-A1 | TERTIARY AMINE DERIVATIVES AS PHOSPHODIESTERASE-4 INHIBITORS | CHIESI FARMACEUTICI S.p.A. (IT) | 2011-01-05 | — | — | EP | claimed |
| US-7820698-B2 | Phosphodiesterase-4 inhibitors belonging to the tertiary amine class | CHIESI FARMACEUTICI S.P.A. (IT) | 2010-10-26 | — | — | US | claimed |
| WO-2009127320-A1 | TERTIARY AMINE DERIVATIVES AS PHOSPHODIESTERASE-4 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-10-22 | — | — | WO | claimed |
| EP-2110375-A1 | Phosphodiesterase-4 inhibitors belonging to the tertiary amine class | CHIESI FARMACEUTICI S.p.A. (IT) | 2009-10-21 | — | — | EP | claimed |
| US-20090258905-A1 | PHOSPHODIESTERASE-4 INHIBITORS BELONGING TO THE TERTIARY AMINE CLASS | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-10-15 | — | — | US | claimed |
| EP-2268632-B1 | TERTIARY AMINE DERIVATIVES AS PHOSPHODIESTERASE-4 INHIBITORS | CHIESI FARMA SPA (IT) | 2012-08-08 | — | — | EP | disclosed |
| US-7820698-B2 | Phosphodiesterase-4 inhibitors belonging to the tertiary amine class | CHIESI FARMACEUTICI S.P.A. (IT) | 2010-10-26 | — | — | US | disclosed |
| EP-2110375-A1 | Phosphodiesterase-4 inhibitors belonging to the tertiary amine class | CHIESI FARMACEUTICI S.p.A. (IT) | 2009-10-21 | — | — | EP | disclosed |
| US-20090258905-A1 | PHOSPHODIESTERASE-4 INHIBITORS BELONGING TO THE TERTIARY AMINE CLASS | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258905-A1 | PHOSPHODIESTERASE-4 INHIBITORS BELONGING TO THE TERTIARY AMINE CLASS | PDE4A, PDE4B, PDE2A | CCR5 3350/4885FNTA 2162/4885FNTB 2247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.