Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.37 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL37695 | 0.87 | KDM4E (0.44) | ALDH1A1MAPTRAB9ASLC5A1SLC5A2 | |
| SCHEMBL15741057 | 0.85 | CCR5 (0.47) | MAPTSLC5A1MEN1KMT2A | |
| SCHEMBL17175 | 0.85 | ESR1 (0.45) | ALDH1A1MAPTRECQLMEN1KMT2A | |
| SCHEMBL12117392 | 0.85 | BCL2 (0.44) | ALDH1A1MAPTCYP3A4CYP2D6CYP2C19 | |
| SCHEMBL31158270 | 0.84 | TAAR1 (0.52) | ALDH1A1TAAR1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL10675819 | 0.84 | TAAR1 (0.52) | ALDH1A1TAAR1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL180996 | 0.82 | SLC5A1 (0.46) | MAOBMAPTNPC1LMNARAB9A | |
| SCHEMBL12363975 | 0.82 | SLC6A4 (0.47) | ALDH1A1MAPTCYP3A4CYP2D6CYP2C19 | |
| SCHEMBL1539254 | 0.81 | SLC5A2 (0.47) | ALDH1A1MAOBHTR7HTR6MAPT | |
| SCHEMBL5551682 | 0.81 | TAAR1 (0.54) | ALDH1A1TAAR1CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9688710-B2 | Inhibitors of sodium glucose cotransporter 1 | LEXICON PHARMACEUTICALS, INC. (US) | 2017-06-27 | — | — | US | disclosed |
| US-20160326205-A1 | INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1 | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2016-11-10 | — | — | US | disclosed |
| US-9200025-B2 | Inhibitors of sodium glucose cotransporter 1 | LEXICON PHARMACEUTICALS, INC. (US) | 2015-12-01 | — | — | US | disclosed |
| US-20140309178-A1 | INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1 | LEXICON PHARMACEUTICALS, INC. (US) | 2014-10-16 | — | — | US | disclosed |
| CN-101998962-A | Novel aromatic fluoroglycoside derivatives, medicaments containing said compounds and the use thereof | SANOFI AVENTIS | 2011-03-30 | — | — | CN | disclosed |
| US-20110059910-A1 | Novel aromatic fluoroglycoside derivatives, pharmaceuticals comprising said compounds and the use thereof | SANOFI-AVENTIS (FR) | 2011-03-10 | — | — | US | disclosed |
| EP-2268653-A2 | NOVEL AROMATIC FLUOROGLYCOSIDE DERIVATIVES, PHARMACEUTICALS COMPRISING SAID COMPOUNDS, AND THE USE THEREOF | Sanofi-Aventis (FR) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009100936-A2 | NOVEL AROMATIC FLUOROGLYCOSIDE DERIVATIVES, PHARMACEUTICALS COMPRISING SAID COMPOUNDS, AND THE USE THEREOF | SANOFI-AVENTIS (FR) | 2009-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059910-A1 | Novel aromatic fluoroglycoside derivatives, pharmaceuticals comprising said compounds and the use thereof | SLC5A2, SLC5A1, SLC2A2 | ALDH1A1 1554/4885MAOB 1135/4885HTR7 1437/4885 |
| US-20140309178-A1 | INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1 | SLC5A1, SLC5A2, SLC2A1 | ALDH1A1 426/4885MAOB 1945/4885HTR7 1889/4885 |
| US-20160326205-A1 | INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1 | SLC5A1, SLC5A2, SLC2A1 | ALDH1A1 426/4885MAOB 1945/4885HTR7 1889/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.