Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SLC5A2 | P31639 | 13/20 | 0.44 |
| ▸ | SLC5A1 | P13866 | 5/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1010022 | 0.87 | ALDH1A1 (0.44) | ALDH1A1POLBSLC5A2SLC5A1PDE3B | |
| SCHEMBL17175 | 0.84 | ESR1 (0.45) | KDM4EALDH1A1POLBSMN1; SMN2MAPT | |
| SCHEMBL15741057 | 0.84 | CCR5 (0.47) | SLC5A1MAPT | |
| SCHEMBL12117392 | 0.83 | BCL2 (0.44) | ALDH1A1POLBMAPTRAB9AALOX5 | |
| SCHEMBL37829 | 0.82 | SLC5A2 (0.51) | KDM4ESMN1; SMN2SLC5A2SLC5A1 | |
| SCHEMBL180996 | 0.81 | SLC5A1 (0.46) | SLC5A2SLC5A1MAPTRAB9A | |
| SCHEMBL12363975 | 0.81 | SLC6A4 (0.47) | ALDH1A1SMN1; SMN2SLC5A2SLC5A1MAPT | |
| SCHEMBL37715 | 0.80 | SLC5A2 (0.47) | KDM4EALDH1A1POLBSMN1; SMN2SLC5A2 | |
| SCHEMBL4813970 | 0.80 | ALDH1A1 (0.61) | KDM4EALDH1A1POLBSMN1; SMN2PDE3B | |
| SCHEMBL8365116 | 0.80 | SMN1; SMN2 (0.41) | KDM4EALDH1A1POLBSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003811-A1 | C-ARYL GLUCOSIDE SGLT2 INHIBITORS AND METHOD | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-12 | — | — | WO | disclosed |