SCHEMBL10100428

SCHEMBL10100428

CN(C)N1C(=O)c2ccc3c4c(ccc(c24)C1=O)C(=O)N(N(C)C)C3=O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TERT O14746 5/20 0.47
NPC1 O15118 3/20 0.42
RAB9A P51151 3/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
STAT3 P40763 1/20 0.42
HIF1A Q16665 1/20 0.42
MEN1 O00255 4/20 0.39
KMT2A Q03164 4/20 0.39
POLB P06746 2/20 0.39
APAF1 O14727 1/20 0.39
CA12 O43570 2/20 0.38
CA1 P00915 2/20 0.38
CA2 P00918 2/20 0.38
CA9 Q16790 2/20 0.38
ALDH1A1 P00352 2/20 0.36
KDM4E B2RXH2 1/20 0.36
RGS12 O14924 1/20 0.36
LMNA P02545 1/20 0.36
PABPC1 P11940 1/20 0.36
HTT P42858 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11956817 0.91 MEN1 (0.50) TERTNPC1RAB9AL3MBTL1STAT3
SCHEMBL11948092 0.83 TERT (0.47) TERTNPC1RAB9AL3MBTL1STAT3
SCHEMBL11948090 0.83 TERT (0.37) TERTNPC1RAB9AL3MBTL1STAT3
SCHEMBL11948091 0.82 TERT (0.39) TERTNPC1RAB9AL3MBTL1STAT3
SCHEMBL6276424 0.81 HEXA (0.57) MEN1KMT2APOLBALDH1A1KDM4E
SCHEMBL873778 0.80 CASP3 (0.52) TERTNPC1RAB9AL3MBTL1HIF1A
SCHEMBL11948089 0.79 TERT (0.37) TERTNPC1RAB9AL3MBTL1STAT3
SCHEMBL17792909 0.76 CYP1B1 (0.63) NPC1L3MBTL1MEN1KMT2APOLB
SCHEMBL10100425 0.75 TERT (0.43) TERTNPC1RAB9AL3MBTL1STAT3
SCHEMBL10100473 0.74 MEN1 (0.40) TERTNPC1RAB9AL3MBTL1STAT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9335645-B2 Electrophotographic photosensitive member, process cartridge and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2016-05-10 US disclosed
US-9335645-B2 Electrophotographic photosensitive member, process cartridge and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2016-05-10 US disclosed
US-20150185633-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2015-07-02 US disclosed
US-20150185633-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2015-07-02 US disclosed
US-8380109-B2 Image forming apparatus and process cartridge RICOH COMPANY, LTD. (JP) 2013-02-19 US disclosed
US-8380109-B2 Image forming apparatus and process cartridge RICOH COMPANY, LTD. (JP) 2013-02-19 US disclosed
US-8110326-B2 Electrophotographic photoreceptor, image forming apparatus, and process cartridge RICOH COMPANY LIMITED (JP) 2012-02-07 US disclosed
US-8110326-B2 Electrophotographic photoreceptor, image forming apparatus, and process cartridge RICOH COMPANY LIMITED (JP) 2012-02-07 US disclosed
US-20090180804-A1 Image forming apparatus and process cartridge RICOH COMPANY, LTD. 2009-07-16 US disclosed
US-20090180804-A1 Image forming apparatus and process cartridge RICOH COMPANY, LTD. 2009-07-16 US disclosed
US-20080298840-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE RICOH COMPANY LIMITED (JP) 2008-12-04 US disclosed
US-20080298840-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE RICOH COMPANY LIMITED (JP) 2008-12-04 US disclosed