SCHEMBL10100516

SCHEMBL10100516

O=C1c2ccc3c4c(ccc(c24)C(=O)N1N1CCCc2ccccc21)C(=O)N(N1CCCc2ccccc21)C3=O

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.45
NOTUM Q6P988 1/20 0.43
ALDH1A1 P00352 5/20 0.42
MAPT P10636 2/20 0.42
MAPK1 P28482 1/20 0.42
SIGMAR1 Q99720 1/20 0.41
HTT P42858 2/20 0.39
HPGD P15428 1/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
CES1 P23141 1/20 0.39
MGLL Q99685 1/20 0.39
NPSR1 Q6W5P4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16864797 0.86 CHRM2 (0.43) SMN1; SMN2NOTUMALDH1A1MAPTMAPK1
SCHEMBL16864806 0.83 USP2 (0.48) SMN1; SMN2ALDH1A1MAPTMAPK1HTT
SCHEMBL20267337 0.80 ALDH1A1 (0.54) NOTUMALDH1A1MAPTMAPK1HTT
SCHEMBL28068349 0.76 KMT2A (0.51) SMN1; SMN2ALDH1A1MAPTHTTHPGD
SCHEMBL28230697 0.74 KMT2A (0.38) SMN1; SMN2ALDH1A1MAPTMAPK1HTT
SCHEMBL28231670 0.72 MEN1 (0.55) SMN1; SMN2ALDH1A1MAPTMAPK1HTT
SCHEMBL10772899 0.71 SMN1; SMN2 (0.50) SMN1; SMN2NOTUMALDH1A1MAPTMAPK1
SCHEMBL4524596 0.70 SMN1; SMN2 (0.46) SMN1; SMN2NOTUMALDH1A1MAPTSIGMAR1
SCHEMBL30530510 0.70 MEN1 (0.44) SMN1; SMN2NOTUMALDH1A1MAPTSIGMAR1
SCHEMBL29466252 0.70 CES1 (0.47) ALDH1A1NPC1RAB9AMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8380109-B2 Image forming apparatus and process cartridge RICOH COMPANY, LTD. (JP) 2013-02-19 US disclosed
US-8380109-B2 Image forming apparatus and process cartridge RICOH COMPANY, LTD. (JP) 2013-02-19 US disclosed
US-8110326-B2 Electrophotographic photoreceptor, image forming apparatus, and process cartridge RICOH COMPANY LIMITED (JP) 2012-02-07 US disclosed
US-8110326-B2 Electrophotographic photoreceptor, image forming apparatus, and process cartridge RICOH COMPANY LIMITED (JP) 2012-02-07 US disclosed
US-20090180804-A1 Image forming apparatus and process cartridge RICOH COMPANY, LTD. 2009-07-16 US disclosed
US-20090180804-A1 Image forming apparatus and process cartridge RICOH COMPANY, LTD. 2009-07-16 US disclosed
US-20080298840-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE RICOH COMPANY LIMITED (JP) 2008-12-04 US disclosed
US-20080298840-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE RICOH COMPANY LIMITED (JP) 2008-12-04 US disclosed