Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 11/20 | 0.38 |
| ▸ | MEN1 | O00255 | 9/20 | 0.38 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | HTT | P42858 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | HBB | P68871 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 4/20 | 0.33 |
| ▸ | CRHBP | P24387 | 2/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28068349 | 0.84 | KMT2A (0.51) | KMT2AMEN1MAPTHTTL3MBTL1 | |
| SCHEMBL28231670 | 0.80 | MEN1 (0.55) | KMT2AMEN1MAPTHTTL3MBTL1 | |
| SCHEMBL20267337 | 0.80 | ALDH1A1 (0.54) | KMT2AMEN1MAPTHTTALDH1A1 | |
| SCHEMBL10100516 | 0.74 | SMN1; SMN2 (0.45) | KMT2AMEN1MAPTHTTALDH1A1 | |
| SCHEMBL28175173 | 0.71 | KMT2A (0.64) | KMT2AMEN1MAPTHTTL3MBTL1 | |
| SCHEMBL28173917 | 0.70 | KEAP1 (0.50) | KMT2AMEN1MAPTHTTL3MBTL1 | |
| SCHEMBL29466252 | 0.70 | CES1 (0.47) | KMT2AMEN1ALDH1A1RAB9ANPC1 | |
| SCHEMBL21336041 | 0.66 | PKM (0.55) | KMT2AMEN1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL28123768 | 0.66 | ALDH1A1 (0.52) | KMT2AMEN1MAPTHTTL3MBTL1 | |
| SCHEMBL30530510 | 0.65 | MEN1 (0.44) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105541855-B | A kind of 1,8- naphthalimide compounds being bonded with spiro-pyrans and preparation method and application | 内蒙古自治区科学技术研究院有限责任公司东部分院 | 2018-08-07 | — | — | CN | claimed |
| CN-105541855-B | A kind of 1,8- naphthalimide compounds being bonded with spiro-pyrans and preparation method and application | 内蒙古自治区科学技术研究院有限责任公司东部分院 | 2018-08-07 | — | — | CN | disclosed |