Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Seridopidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 5/20 | 0.42 |
| ▸ | HTR6 | P50406 | 3/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Seridopidine SCHEMBL29941400 | 0.99 | DRD2 (0.53) | DRD2SIGMAR1HRH3DRD3HTR6 | |
| Seridopidine SCHEMBL1008691 | 0.99 | DRD2 (0.53) | DRD2SIGMAR1HRH3DRD3HTR6 | |
| Hydrochloric Acid SCHEMBL1010782 | 0.89 | DRD2 (0.67) | DRD2SIGMAR1DRD3HTR6 | |
| SCHEMBL1009377 | 0.88 | DRD2 (0.68) | DRD2SIGMAR1DRD3HTR6 | |
| SCHEMBL1009679 | 0.83 | DRD2 (0.46) | DRD2SIGMAR1DRD3NPY5RHCRTR2 | |
| SCHEMBL4824639 | 0.79 | DRD2 (0.80) | DRD2SIGMAR1HRH3DRD3HTR6 | |
| SCHEMBL5550396 | 0.77 | DRD2 (0.48) | DRD2DRD3KDM4E | |
| SCHEMBL1011686 | 0.75 | HTR6 (0.41) | SIGMAR1HTR6HCRTR2 | |
| SCHEMBL1821857 | 0.74 | DRD2 (0.52) | DRD2KDM4E | |
| SCHEMBL8242625 | 0.74 | KDM4E (0.39) | DRD2HRH3DRD3KDM4EMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011107583-A1 | SUBSTITUTED 4-PHENYL-N-ALKYL-PIPERIDINES FOR PREVENTING ONSET OR SLOWING PROGRESSION OF NEURODEGENERATIVE DISORDERS | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2011-09-09 | — | — | WO | claimed |
| EP-1948606-B1 | 3, 5-DISUBSTITUTED PHENYL-PIPERIDINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | NSAB AF NEUROSEARCH SWEDEN AB (DK) | 2011-01-05 | — | — | EP | claimed |
| WO-2011107583-A1 | SUBSTITUTED 4-PHENYL-N-ALKYL-PIPERIDINES FOR PREVENTING ONSET OR SLOWING PROGRESSION OF NEURODEGENERATIVE DISORDERS | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2011-09-09 | — | — | WO | disclosed |