Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.34 |
| ▸ | CCR5 | P51681 | 2/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Seridopidine SCHEMBL29941400 | 0.84 | DRD2 (0.53) | DRD2SIGMAR1DRD3NPY5RHCRTR2 | |
| Seridopidine SCHEMBL1008691 | 0.84 | DRD2 (0.53) | DRD2SIGMAR1DRD3NPY5RHCRTR2 | |
| Seridopidine SCHEMBL1010113 | 0.83 | DRD2 (0.52) | DRD2SIGMAR1DRD3NPY5RHCRTR2 | |
| SCHEMBL4825019 | 0.82 | DRD2 (0.69) | DRD2SIGMAR1DRD3NR1H2NR1H3 | |
| SCHEMBL1009377 | 0.82 | DRD2 (0.68) | DRD2SIGMAR1DRD3 | |
| Hydrochloric Acid SCHEMBL1010782 | 0.81 | DRD2 (0.67) | DRD2SIGMAR1DRD3 | |
| SCHEMBL1011686 | 0.72 | HTR6 (0.41) | SIGMAR1HCRTR2PTGS2 | |
| SCHEMBL2781495 | 0.70 | SIGMAR1 (0.39) | DRD2SIGMAR1DRD3HCRTR2DRD4 | |
| SCHEMBL82136 | 0.67 | SLC18A3 (0.45) | DRD2DRD3DRD4 | |
| SCHEMBL175904 | 0.67 | SLC18A3 (0.57) | DRD2SIGMAR1CCR5DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948606-B1 | 3, 5-DISUBSTITUTED PHENYL-PIPERIDINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | NSAB AF NEUROSEARCH SWEDEN AB (DK) | 2011-01-05 | — | — | EP | claimed |
| US-20080234321-A1 | 3,5-Disubstituted Phenyl-Piperidines as Modulators of Dopamine Neurotransmission | SANIONA AB (DK) | 2008-09-25 | — | — | US | claimed |
| US-8501777-B2 | 1-ethyl-4-[3-fluoro-5-(methylsulfonyl)phenyl]piperidine; central nervous system disorders, Parkinson's disease, Parkinsonism, dyskinesias, including L-DOPA induced dyskinesias, dystonias, tics, tremor, Huntington disease | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2013-08-06 | — | — | US | disclosed |
| EP-1948606-B1 | 3, 5-DISUBSTITUTED PHENYL-PIPERIDINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | NSAB AF NEUROSEARCH SWEDEN AB (DK) | 2011-01-05 | — | — | EP | disclosed |
| US-20080234321-A1 | 3,5-Disubstituted Phenyl-Piperidines as Modulators of Dopamine Neurotransmission | SANIONA AB (DK) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234321-A1 | 3,5-Disubstituted Phenyl-Piperidines as Modulators of Dopamine Neurotransmission | SLC6A3, DRD2, DRD3 | DRD2 2/4885SIGMAR1 148/4885DRD3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.