SCHEMBL10101277

SCHEMBL10101277

CC(C)OC(=O)N1CCC(COc2cc(-c3ccc(C[C@H](N)C(=O)N4CC[C@H](F)C4)c(F)c3)ccn2)CC1

nearest known ligand 0.45

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 15/20 0.45
DPP4 P27487 5/20 0.41
DPP7 Q9UHL4 3/20 0.39
DPP8 Q6V1X1 2/20 0.39
DPP9 Q86TI2 2/20 0.39
KCNH2 Q12809 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL865850 1.00 GPR119 (0.45) GPR119DPP4DPP7DPP8DPP9
Hydrochloric Acid SCHEMBL865378 0.99 GPR119 (0.44) GPR119DPP4DPP7DPP8DPP9
Hydrochloric Acid SCHEMBL865851 0.99 GPR119 (0.44) GPR119DPP4DPP7DPP8DPP9
SCHEMBL863657 0.91 GPR119 (0.47) GPR119DPP4DPP7DPP8DPP9
SCHEMBL863658 0.91 GPR119 (0.47) GPR119DPP4DPP7DPP8DPP9
SCHEMBL863656 0.91 GPR119 (0.47) GPR119DPP4DPP7DPP8DPP9
SCHEMBL864705 0.89 GPR119 (0.51) GPR119DPP4DPP7DPP8DPP9
SCHEMBL864160 0.89 GPR119 (0.51) GPR119DPP4DPP7DPP8DPP9
SCHEMBL864161 0.89 GPR119 (0.51) GPR119DPP4DPP7DPP8DPP9
SCHEMBL10101271 0.87 GPR119 (0.47) GPR119DPP4DPP7DPP8DPP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120077793-A1 Compounds for the Treatment of Metabolic Disorders PROSIDION LIMITED (GB) 2012-03-29 US disclosed
US-20120077793-A1 Compounds for the Treatment of Metabolic Disorders PROSIDION LIMITED (GB) 2012-03-29 US disclosed
WO-2010103333-A1 COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS PROSIDION LIMITED (GB) 2010-09-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120077793-A1 Compounds for the Treatment of Metabolic Disorders GPR119, GPR132, FFAR2 GPR119 1/4885DPP4 217/4885DPP7 276/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.