Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | VNN1 | O95497 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22359131 | 0.82 | POLB (0.56) | POLBUSP2CYP3A4TSHR | |
| SCHEMBL10101641 | 0.78 | POLB (0.45) | POLBVNN1 | |
| SCHEMBL10101683 | 0.77 | POLB (0.48) | POLBUSP2BAZ2B | |
| SCHEMBL17177138 | 0.75 | POLB (0.56) | POLB | |
| SCHEMBL14022394 | 0.75 | CYP1A2 (0.48) | USP2CYP3A4TSHR | |
| SCHEMBL19504452 | 0.74 | USP2 (0.56) | USP2CYP3A4TSHR | |
| SCHEMBL20669138 | 0.74 | CYP2D6 (0.48) | POLBUSP2CYP3A4TSHR | |
| SCHEMBL17113706 | 0.73 | POLB (0.54) | POLBEPHX2 | |
| SCHEMBL17113709 | 0.73 | POLB (0.54) | POLB | |
| SCHEMBL24629422 | 0.73 | USP2 (0.34) | USP2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120083476-A1 | HETEROARYL-SUBSTITUTED SPIROCYCLIC DIAMINE UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE | JANSSEN PHARMACEUTICA NV (BE) | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083476-A1 | HETEROARYL-SUBSTITUTED SPIROCYCLIC DIAMINE UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE | FAAH, FAAH2, DBH | POLB 1736/4885USP2 75/4885VNN1 1659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.