Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 8/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.43 |
| ▸ | LOX | P28300 | 6/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3288094 | 0.85 | LOXL2 (0.61) | LOXL2LOX | |
| SCHEMBL13452508 | 0.85 | LOXL2 (0.47) | LOXL2NR1H2NR1H3LOXF10 | |
| SCHEMBL1011166 | 0.85 | LOXL2 (0.43) | LOXL2PPARGLOXRETDRD1 | |
| SCHEMBL27209663 | 0.82 | LOXL2 (0.44) | LOXL2NR1H2NR1H3LOXF10 | |
| SCHEMBL21328434 | 0.80 | PPARG (0.46) | LOXL2PPARGLOXF10KDR | |
| SCHEMBL1747080 | 0.80 | MGLL (0.47) | LOXL2LOXGPBAR1CYSLTR1TSHR | |
| SCHEMBL1011129 | 0.79 | NR1H2 (0.46) | PPARGNR1H2NR1H3F10KDR | |
| SCHEMBL1747441 | 0.79 | ALDH1A1 (0.53) | NR1H2NR1H3F10TSHRSMN1; SMN2 | |
| SCHEMBL30979256 | 0.79 | ALDH1A1 (0.53) | NR1H2NR1H3F10TSHRSMN1; SMN2 | |
| SCHEMBL3158059 | 0.79 | LOXL2 (0.44) | LOXL2LOXF10GPBAR1CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044052-B2 | Inhibitors of fatty acid amide hydrolase; N-pyridin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxamide; elevate brain anandamide levels; pain, urinary incontinence, cognitive disorders, anxiety, depression, sleeping, eating, movement disorders, glaucoma, psoriasis | PFIZER INC. (US) | 2011-10-25 | — | — | US | disclosed |
| EP-2076508-B1 | BIARYL ETHER UREA COMPOUNDS | PFIZER PROD INC (US) | 2011-01-05 | — | — | EP | disclosed |