Sugi Predict

Sugi Predict / Compounds / SCHEMBL101046

SCHEMBL101046

SCHEMBL101046

CC1=Nc2cccc(C(=O)O)c2C1(C)C

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 3/20 0.46
▸ MEN1 O00255 2/20 0.46
▸ ALDH1A1 P00352 4/20 0.42
▸ KDM4E B2RXH2 3/20 0.42
▸ HPGD P15428 2/20 0.42
▸ HSD17B10 Q99714 2/20 0.42
▸ TDP1 Q9NUW8 2/20 0.39
▸ ALOX15 P16050 2/20 0.39
▸ MYC P01106 3/20 0.39
▸ TSHR P16473 2/20 0.37
▸ CYP3A4 P08684 2/20 0.37
▸ CYP2C9 P11712 2/20 0.37
▸ POLB P06746 2/20 0.36
▸ NR4A1 P22736 2/20 0.35
▸ NR4A2 P43354 1/20 0.35
▸ NR4A3 Q92570 1/20 0.35
▸ AKR1C3 P42330 2/20 0.35
▸ AKR1B10 O60218 1/20 0.35
▸ TRPA1 O75762 1/20 0.35
▸ ABCB11 O95342 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8027852 0.81 MEN1 (0.45) KMT2AMEN1ALDH1A1KDM4EHPGD
SCHEMBL1049879 0.74 MEN1 (0.55) KMT2AMEN1ALDH1A1TSHRCYP1A2
SCHEMBL4014873 0.70 MEN1 (0.47) KMT2AMEN1KDM4ETDP1MYC
SCHEMBL27552497 0.68 TSHR (0.59) KMT2AMEN1ALDH1A1KDM4EHPGD
Benzene SCHEMBL27265959 0.66 TSHR (0.61) KMT2AMEN1ALDH1A1KDM4EHPGD
SCHEMBL756585 0.66 TSHR (0.61) KMT2AMEN1ALDH1A1KDM4EHPGD
SCHEMBL27703149 0.66 TSHR (0.61) KMT2AMEN1ALDH1A1KDM4EHPGD
SCHEMBL10768142 0.64 TSHR (0.59) KMT2AMEN1ALDH1A1KDM4EHPGD
Ammonia Solution, Strong SCHEMBL27776892 0.64 TSHR (0.59) KMT2AMEN1ALDH1A1KDM4EHPGD
Ethane SCHEMBL27288094 0.64 TSHR (0.59) KMT2AMEN1ALDH1A1KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020181931-A1 HEPTAMETHINE CARBOXYLINDOLE CYANINE DYE AND PREPARATION METHOD AND APPLICATION THEREFOR 中国科学院宁波工业技术研究院慈溪生物医学工程研究所 2020-09-17 — — WO claimed
CN-111662567-A Heptamethine carboxyl indole cyanine dye and preparation method and application thereof 中国科学院宁波材料技术与工程研究所 2020-09-15 — — CN claimed
US-12624391-B2 Cyanine dyes PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2026-05-12 — — US disclosed
US-20240132948-A1 Cyanine Dyes PACIFIC BIOSCIENCES OF CALIFORNIA, INC. 2024-04-25 — — US disclosed
US-11624089-B2 Cyanine dyes PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2023-04-11 — — US disclosed
US-11624089-B2 Cyanine dyes PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2023-04-11 — — US disclosed
WO-2020181931-A1 HEPTAMETHINE CARBOXYLINDOLE CYANINE DYE AND PREPARATION METHOD AND APPLICATION THEREFOR 中国科学院宁波工业技术研究院慈溪生物医学工程研究所 2020-09-17 — — WO disclosed
CN-111662567-A Heptamethine carboxyl indole cyanine dye and preparation method and application thereof 中国科学院宁波材料技术与工程研究所 2020-09-15 — — CN disclosed
US-20200232023-A1 CYANINE DYES PACIFIC BIOSCIENCES OF CALIFORNIA, INC. 2020-07-23 — — US disclosed
US-20200232023-A1 CYANINE DYES PACIFIC BIOSCIENCES OF CALIFORNIA, INC. 2020-07-23 — — US disclosed
US-10392659-B2 Cyanine dyes PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2019-08-27 — — US disclosed
US-20120058469-A1 FUNCTIONALIZED CYANINE DYES (PEG) PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2012-03-08 — — US disclosed
US-20120058469-A1 FUNCTIONALIZED CYANINE DYES (PEG) PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2012-03-08 — — US disclosed
US-20120052506-A1 CYANINE DYES PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2012-03-01 — — US disclosed
US-20120052506-A1 CYANINE DYES PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2012-03-01 — — US disclosed
US-20120052506-A1 CYANINE DYES PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2012-03-01 — — US disclosed
WO-2012027618-A2 FUNCTIONALIZED CYANINE DYES PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2012-03-01 — — WO disclosed
WO-2012027618-A2 FUNCTIONALIZED CYANINE DYES PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2012-03-01 — — WO disclosed
WO-2012027623-A2 CYANINE DYES PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2012-03-01 — — WO disclosed
WO-2012027623-A2 CYANINE DYES PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2012-03-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240132948-A1 Cyanine Dyes ABCG2, IK, ACR KMT2A 2564/4885MEN1 2288/4885ALDH1A1 1447/4885
US-10392659-B2 Cyanine dyes ABCG2, IK, ACR KMT2A 2564/4885MEN1 2288/4885ALDH1A1 1447/4885
US-11624089-B2 Cyanine dyes ABCG2, IK, ACR KMT2A 2564/4885MEN1 2288/4885ALDH1A1 1447/4885
US-20120052506-A1 CYANINE DYES ABCG2, IK, ACR KMT2A 2564/4885MEN1 2288/4885ALDH1A1 1447/4885
US-20200232023-A1 CYANINE DYES ABCG2, IK, ACR KMT2A 2564/4885MEN1 2288/4885ALDH1A1 1447/4885
US-12624391-B2 Cyanine dyes POLL, POLR2E, POLR2H KMT2A 2631/4885MEN1 4800/4885ALDH1A1 3243/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.