SCHEMBL1010564

SCHEMBL1010564

CCOc1ccc(C(C=O)c2cc(Cl)c(O)cc2O)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 3/20 0.44
HSP90AA1 P07900 2/20 0.43
HSP90AB1 P08238 1/20 0.43
L3MBTL1 Q9Y468 3/20 0.39
MEN1 O00255 3/20 0.39
ALDH1A1 P00352 3/20 0.39
KMT2A Q03164 3/20 0.39
MAPT P10636 3/20 0.39
GAA P10253 3/20 0.39
TDP1 Q9NUW8 2/20 0.39
MAPK1 P28482 1/20 0.39
TSHR P16473 1/20 0.39
LMNA P02545 1/20 0.38
TP53 P04637 1/20 0.38
HTT P42858 1/20 0.38
HSD17B10 Q99714 1/20 0.38
ERN1 O75460 2/20 0.37
AKR1C3 P42330 1/20 0.37
AKR1C2 P52895 1/20 0.37
SLC5A1 P13866 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1010013 0.86 HSP90AA1 (0.41) DPP4HSP90AA1HSP90AB1L3MBTL1MEN1
SCHEMBL1010298 0.85 HSP90AA1 (0.44) HSP90AA1HSP90AB1L3MBTL1MEN1ALDH1A1
SCHEMBL1011525 0.82 HSP90AA1 (0.38) HSP90AA1HSP90AB1L3MBTL1MEN1ALDH1A1
SCHEMBL484707 0.80 DPP4 (0.45) DPP4HSP90AA1HSP90AB1L3MBTL1MEN1
SCHEMBL1010039 0.76 HSP90AA1 (0.41) DPP4HSP90AA1HSP90AB1L3MBTL1MEN1
SCHEMBL27640494 0.70 LMNA (0.44) HSP90AA1TSHRLMNAHSD17B10ERN1
SCHEMBL15346833 0.70 MAPT (0.43) MEN1ALDH1A1KMT2AMAPTGAA
SCHEMBL29262773 0.69 NQO1 (0.52) L3MBTL1MEN1KMT2ATDP1TSHR
SCHEMBL15330491 0.68 NQO1 (0.56) TDP1TSHRLMNANQO1LTA4H
SCHEMBL2221195 0.68 NQO1 (0.50) DPP4HSP90AA1HSP90AB1L3MBTL1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2268626-A1 5-ARYL-4-(5-SUBSTITUTED 2,4-DIHYDROXYPHENYL)-1,2,3-THIADIAZOLES AS INHIBITORS OF HSP90 CHAPERONE AND THE INTERMEDIATES FOR PRODUCTION THEREOF Biotechnologijos Institutas (LT) 2011-01-05 EP disclosed
WO-2009134110-A1 5-ARYL-4-(5-SUBSTITUTED 2,4-DIHYDROXYPHENYL)-1,2,3-THIADIAZOLES AS INHIBITORS OF HSP90 CHAPERONE AND THE INTERMEDIATES FOR PRODUCTION THEREOF BIOTECHNOLOGIJOS INSTITUTAS (LT) 2009-11-05 WO disclosed