SCHEMBL1010013

SCHEMBL1010013

COc1ccc(C(C=O)c2cc(Cl)c(O)cc2O)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 9/20 0.41
DPP4 P27487 1/20 0.41
TCF4 P15884 1/20 0.40
CTNNB1 P35222 1/20 0.40
CYP3A4 P08684 2/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
ALOX15 P16050 1/20 0.39
CYP2C19 P33261 1/20 0.39
HSP90AB1 P08238 2/20 0.39
TYR P14679 2/20 0.39
ERN1 O75460 1/20 0.39
TRIM24 O15164 1/20 0.39
TRIM33 Q9UPN9 1/20 0.39
KMT2A Q03164 3/20 0.37
MEN1 O00255 2/20 0.37
MAPT P10636 2/20 0.37
PPARG P37231 1/20 0.37
BCHE P06276 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1010564 0.86 DPP4 (0.44) HSP90AA1DPP4HSP90AB1ERN1KMT2A
SCHEMBL1011525 0.84 HSP90AA1 (0.38) HSP90AA1HSP90AB1TYRKMT2AMEN1
SCHEMBL1010039 0.84 HSP90AA1 (0.41) HSP90AA1DPP4CYP1A2CYP2C9CYP2C19
SCHEMBL3955351 0.80 MEN1 (0.51) HSP90AA1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL485336 0.79 HSP90AA1 (0.45) HSP90AA1DPP4CYP3A4CYP1A2CYP2D6
SCHEMBL4731187 0.78 TYR (0.49) CYP3A4CYP1A2CYP2D6CYP2C9ALOX15
SCHEMBL5188701 0.77 MAPT (0.44) KMT2AMEN1MAPTRAB9AKDM4E
SCHEMBL11558512 0.77 ACP3 (0.44) CYP3A4CYP1A2CYP2D6CYP2C9ALOX15
SCHEMBL5202082 0.76 TYR (0.47) CYP3A4CYP1A2CYP2D6CYP2C9ALOX15
SCHEMBL4970732 0.75 MAPT (0.36) HSP90AA1TCF4CTNNB1CYP3A4ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2268626-A1 5-ARYL-4-(5-SUBSTITUTED 2,4-DIHYDROXYPHENYL)-1,2,3-THIADIAZOLES AS INHIBITORS OF HSP90 CHAPERONE AND THE INTERMEDIATES FOR PRODUCTION THEREOF Biotechnologijos Institutas (LT) 2011-01-05 EP disclosed
WO-2009134110-A1 5-ARYL-4-(5-SUBSTITUTED 2,4-DIHYDROXYPHENYL)-1,2,3-THIADIAZOLES AS INHIBITORS OF HSP90 CHAPERONE AND THE INTERMEDIATES FOR PRODUCTION THEREOF BIOTECHNOLOGIJOS INSTITUTAS (LT) 2009-11-05 WO disclosed