SCHEMBL1010039

SCHEMBL1010039

COc1ccc(C(C=O)c2cc(Cl)c(O)cc2O)cc1OC

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 3/20 0.41
SMN1; SMN2 Q16637 3/20 0.40
GAA P10253 1/20 0.40
KMT2A Q03164 3/20 0.39
NPC1 O15118 3/20 0.39
RAB9A P51151 3/20 0.39
MEN1 O00255 2/20 0.39
HTT P42858 2/20 0.39
HSP90AB1 P08238 1/20 0.39
NQO2 P16083 1/20 0.39
ACHE P22303 2/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
DPP4 P27487 1/20 0.38
PPARG P37231 1/20 0.38
PPARD Q03181 1/20 0.38
PPARA Q07869 1/20 0.38
TNF P01375 2/20 0.37
NPSR1 Q6W5P4 2/20 0.37
CYP1A2 P05177 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1010013 0.84 HSP90AA1 (0.41) HSP90AA1GAAKMT2ANPC1RAB9A
SCHEMBL5490550 0.81 ALDH1A1 (0.43) SMN1; SMN2GAAKMT2AMEN1ACHE
SCHEMBL485191 0.80 HSP90AA1 (0.44) HSP90AA1SMN1; SMN2KMT2ANPC1RAB9A
SCHEMBL4684702 0.80 ACHE (0.45) SMN1; SMN2GAAKMT2AMEN1HTT
SCHEMBL1011525 0.79 HSP90AA1 (0.38) HSP90AA1GAAKMT2ANPC1RAB9A
SCHEMBL6989802 0.77 AKR1C3 (0.44) SMN1; SMN2GAAKMT2AACHECA1
SCHEMBL5493143 0.76 TSHR (0.40) SMN1; SMN2GAAKMT2AACHECA1
SCHEMBL1010564 0.76 DPP4 (0.44) HSP90AA1GAAKMT2AMEN1HTT
SCHEMBL4070600 0.73 BCHE (0.52) GAAKMT2AMEN1ACHENPSR1
SCHEMBL22365701 0.72 TYR (0.65) ACHENPSR1ALDH1A1TDP1BLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2268626-A1 5-ARYL-4-(5-SUBSTITUTED 2,4-DIHYDROXYPHENYL)-1,2,3-THIADIAZOLES AS INHIBITORS OF HSP90 CHAPERONE AND THE INTERMEDIATES FOR PRODUCTION THEREOF Biotechnologijos Institutas (LT) 2011-01-05 EP disclosed
WO-2009134110-A1 5-ARYL-4-(5-SUBSTITUTED 2,4-DIHYDROXYPHENYL)-1,2,3-THIADIAZOLES AS INHIBITORS OF HSP90 CHAPERONE AND THE INTERMEDIATES FOR PRODUCTION THEREOF BIOTECHNOLOGIJOS INSTITUTAS (LT) 2009-11-05 WO disclosed