Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10105725 | 0.86 | — | — | |
| SCHEMBL10105714 | 0.84 | TRPA1 (0.38) | DHODH | |
| SCHEMBL10105742 | 0.83 | AAK1 (0.35) | AAK1DHODH | |
| SCHEMBL10105734 | 0.82 | AAK1 (0.32) | AAK1 | |
| SCHEMBL10105711 | 0.79 | DHODH (0.45) | DHODH | |
| SCHEMBL12271439 | 0.79 | TRPA1 (0.39) | — | |
| SCHEMBL10105721 | 0.79 | GPR119 (0.41) | — | |
| SCHEMBL10105723 | 0.75 | GPR119 (0.38) | DHODH | |
| SCHEMBL10105778 | 0.75 | GPR119 (0.41) | — | |
| SCHEMBL10105720 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040975-A1 | BRIDGED BICYCLIC HETEROCYCLE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME CORP. | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040975-A1 | BRIDGED BICYCLIC HETEROCYCLE DERIVATIVES AND METHODS OF USE THEREOF | GPR119, BDKRB2, GLP1R | AAK1 2233/4885DHODH 1203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.