SCHEMBL10107100

SCHEMBL10107100

O[C@H]1C[C@H]2CC[C@@H](C1)N2c1ccc(C(F)(F)F)cn1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.48
ABL1 P00519 1/20 0.48
LMNA P02545 1/20 0.48
MAPT P10636 5/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
ALDH1A1 P00352 3/20 0.44
APAF1 O14727 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
TMEM97 Q5BJF2 1/20 0.42
SIGMAR1 Q99720 1/20 0.42
CYP3A4 P08684 2/20 0.41
AR P10275 1/20 0.41
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
HPGD P15428 1/20 0.40
CYP2C9 P11712 2/20 0.39
CYP2C19 P33261 2/20 0.39
GPR119 Q8TDV5 1/20 0.39
CYP1A2 P05177 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL385240 1.00 KDM4E (0.48) KDM4EABL1LMNAMAPTSMN1; SMN2
SCHEMBL13813125 1.00 KDM4E (0.48) KDM4EABL1LMNAMAPTSMN1; SMN2
SCHEMBL10107239 1.00 KDM4E (0.48) KDM4EABL1LMNAMAPTSMN1; SMN2
SCHEMBL13799807 1.00 KDM4E (0.48) KDM4EABL1LMNAMAPTSMN1; SMN2
SCHEMBL16433630 0.85 KDM4E (0.45) KDM4EABL1LMNAMAPTSMN1; SMN2
SCHEMBL12861202 0.85 KDM4E (0.48) KDM4EABL1LMNAMAPTSMN1; SMN2
SCHEMBL3648206 0.80 AR (0.41) KDM4EABL1LMNATMEM97SIGMAR1
SCHEMBL4285774 0.80 AR (0.41) KDM4EABL1LMNATMEM97SIGMAR1
SCHEMBL2299564 0.80 LIPE (0.45) KDM4EABL1LMNALIPEHRH3
SCHEMBL12153025 0.80 LIPE (0.45) KDM4EABL1LMNALIPEHRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE45364-E1 Cyclic amine compound and pest control agent NIPPON SODA CO., LTD. (JP) 2015-02-03 US disclosed
US-RE45364-E1 Cyclic amine compound and pest control agent NIPPON SODA CO., LTD. (JP) 2015-02-03 US disclosed
EP-1731518-B1 CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO (JP) 2014-06-25 EP disclosed
US-8536340-B2 Cross-linked cyclic amine compounds and agents for pest control NIPPON SODA CO., LTD. (JP) 2013-09-17 US disclosed
US-8338607-B2 Cyclic amine compounds and agents for pest control NIPPON SODA CO., LTD. (JP) 2012-12-25 US disclosed
US-8338607-B2 Cyclic amine compounds and agents for pest control NIPPON SODA CO., LTD. (JP) 2012-12-25 US disclosed
US-8101768-B2 Cyclic amine compound and pest control agent NIPPON SODA CO., LTD. (JP) 2012-01-24 US disclosed
US-8101768-B2 Cyclic amine compound and pest control agent NIPPON SODA CO., LTD. (JP) 2012-01-24 US disclosed
US-20110257389-A1 CROSS-LINKED CYCLIC AMINE COMPOUNDS AND AGENTS FOR PEST CONTROL NIPPON SODA CO., LTD. (JP) 2011-10-20 US disclosed
US-7999102-B2 Cross-linked cyclic amine compounds and agents for pest control NIPPON SODA CO., LTD. (JP) 2011-08-16 US disclosed
US-20090259046-A1 Cyclic Amine Compounds and Agents for Pest Control NIPPON SODA CO., LTD. (JP) 2009-10-15 US disclosed
US-20090143443-A1 CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2009-06-04 US disclosed
US-20090143443-A1 CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2009-06-04 US disclosed
US-7485727-B2 Cyclic amine compound and pest control agent NIPPON SODA CO., LTD. (JP) 2009-02-03 US disclosed
US-7485727-B2 Cyclic amine compound and pest control agent NIPPON SODA CO., LTD. (JP) 2009-02-03 US disclosed
US-20080319003-A1 CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2008-12-25 US disclosed
US-20080319003-A1 CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2008-12-25 US disclosed
EP-1932844-A1 BRIDGED CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2008-06-18 EP disclosed
US-20080045569-A1 Cyclic Amine Compound and Pest Control Agent NIPPON SODA CO., LTD. (JP) 2008-02-21 US disclosed
US-20080045569-A1 Cyclic Amine Compound and Pest Control Agent NIPPON SODA CO., LTD. (JP) 2008-02-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080045569-A1 Cyclic Amine Compound and Pest Control Agent H1-0, H1-2, H1-4 KDM4E 373/4885ABL1 876/4885LMNA 2290/4885
US-20110257389-A1 CROSS-LINKED CYCLIC AMINE COMPOUNDS AND AGENTS FOR PEST CONTROL CYCS, NPY1R, CYBB KDM4E 1600/4885ABL1 1967/4885LMNA 2317/4885
US-20090259046-A1 Cyclic Amine Compounds and Agents for Pest Control NPR1, CYCS, CYC1 KDM4E 1178/4885ABL1 615/4885LMNA 2910/4885
US-20090143443-A1 CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT TAAR1, CBR3, CBR1 KDM4E 1169/4885ABL1 1511/4885LMNA 3072/4885
US-20080319003-A1 CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT H1-0, H1-2, H1-4 KDM4E 339/4885ABL1 873/4885LMNA 2360/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.