Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.66 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20677846 | 0.80 | HSP90AA1 (1.00) | HSP90AA1HPGDPDE7BMEN1KMT2A | |
| SCHEMBL11390038 | 0.78 | HPGD (0.64) | HSP90AA1HPGDTSHRALDH1A1GAA | |
| SCHEMBL12632572 | 0.78 | HSP90AA1 (0.60) | HSP90AA1HPGDTSHRALDH1A1GAA | |
| SCHEMBL8299002 | 0.77 | HSP90AA1 (0.65) | HSP90AA1HPGDPDE7BTSHRALDH1A1 | |
| SCHEMBL95064 | 0.76 | HPGD (0.65) | HSP90AA1HPGDTSHRALDH1A1GAA | |
| SCHEMBL4768048 | 0.75 | HPGD (0.54) | HSP90AA1HPGDTSHRALDH1A1GAA | |
| SCHEMBL503808 | 0.74 | ALDH2 (1.00) | HSP90AA1ALDH2HPGDTSHRALDH1A1 | |
| SCHEMBL3235551 | 0.74 | HSP90AA1 (0.58) | HSP90AA1HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL8349898 | 0.74 | TRPM8 (0.62) | HSP90AA1HPGDTSHRALDH1A1KMT2A | |
| SCHEMBL7853871 | 0.73 | ALDH2 (0.80) | ALDH2HPGDTSHRGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9315484-B2 | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof | The Board of Trustees—Leland Stanford Junior University (US) | 2016-04-19 | — | — | US | disclosed |
| US-9315484-B2 | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof | The Board of Trustees—Leland Stanford Junior University (US) | 2016-04-19 | — | — | US | disclosed |
| US-9273025-B2 | — | — | 2016-03-01 | — | — | US | disclosed |
| US-9273025-B2 | — | — | 2016-03-01 | — | — | US | disclosed |
| US-9102651-B2 | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof | The Board of Trustees-Leland Stanford Junior University (US) | 2015-08-11 | — | — | US | disclosed |
| US-9102651-B2 | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof | The Board of Trustees-Leland Stanford Junior University (US) | 2015-08-11 | — | — | US | disclosed |
| US-20150105456-A1 | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2015-04-16 | — | — | US | disclosed |
| US-20150105456-A1 | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2015-04-16 | — | — | US | disclosed |
| US-20120010248-A1 | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-01-12 | — | — | US | disclosed |
| US-20110105602-A2 | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-05-05 | — | — | US | disclosed |
| US-20090082431-A1 | MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-03-26 | — | — | US | disclosed |
| WO-2008112164-A2 | MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS AND METHODS OF USE THEREOF | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2008-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105456-A1 | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof | ALDH2, ALDH5A1, AK2 | HSP90AA1 718/4885ALDH2 1/4885HPGD 184/4885 |
| US-20110105602-A2 | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof | ALDH2, ALDH5A1, AK2 | HSP90AA1 718/4885ALDH2 1/4885HPGD 184/4885 |
| US-20120010248-A1 | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof | ALDH2, ALDH5A1, AK2 | HSP90AA1 718/4885ALDH2 1/4885HPGD 184/4885 |
| US-20090082431-A1 | MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS AND METHODS OF USE THEREOF | ALDH2, ALDH5A1, AK2 | HSP90AA1 718/4885ALDH2 1/4885HPGD 184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.