Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 6/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 2/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10108330 | 0.79 | CYP1A2 (0.31) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10108149 | 0.65 | CYP1A2 (0.31) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL24168410 | 0.63 | ADORA2A (0.40) | ALDH1A1SMN1; SMN2PDE4APDE4BPDE4C | |
| SCHEMBL5657414 | 0.61 | ADORA2A (0.38) | ALDH1A1SMN1; SMN2PDE4APDE4BPDE4C | |
| SCHEMBL22670134 | 0.61 | ADORA2A (0.38) | ALDH1A1SMN1; SMN2PDE4APDE4BPDE4C | |
| SCHEMBL10108323 | 0.60 | CSNK2A1 (0.43) | ALDH1A1SMN1; SMN2PDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL3460642 | 0.60 | ADORA2A (0.37) | ALDH1A1SMN1; SMN2PDE4APDE4BPDE4C | |
| SCHEMBL18050872 | 0.59 | PKM (0.57) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL11743821 | 0.58 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL3758100 | 0.58 | NPSR1 (0.34) | ADORA2AADORA1CDK1CCNB1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077811-A1 | PRODRUG FORMS OF KINASE INHIBITORS AND THEIR USE IN THERAPY | AUCKLAND UNISERVICES LIMITED (NZ) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077811-A1 | PRODRUG FORMS OF KINASE INHIBITORS AND THEIR USE IN THERAPY | NTRK3, TK1, TNNI3K | ALDH1A1 3257/4885SMN1; SMN2 4190/4885PDE4A 1127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.