Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | USP28 | Q96RU2 | 2/20 | 0.44 |
| ▸ | USP25 | Q9UHP3 | 2/20 | 0.44 |
| ▸ | CCR5 | P51681 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1061939 | 0.80 | MEN1 (0.53) | ALDH1A1HTTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL1943673 | 0.80 | KDM4E (0.53) | ALDH1A1HTTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL2280306 | 0.77 | FFAR1 (0.44) | — | |
| SCHEMBL3484087 | 0.76 | NAAA (0.42) | ALDH1A1MEN1KMT2AKDM4ECCR5 | |
| SCHEMBL6259183 | 0.75 | SMN1; SMN2 (0.63) | ALDH1A1HTTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL1644681 | 0.74 | F10 (0.44) | LMNAMEN1KMT2AMAPK1NPSR1 | |
| SCHEMBL1644135 | 0.74 | F10 (0.44) | ALDH1A1LMNAMEN1KMT2ANPSR1 | |
| SCHEMBL8155074 | 0.74 | CCR5 (0.53) | ALDH1A1HTTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL2278370 | 0.74 | F10 (0.42) | SMN1; SMN2LMNAMEN1KMT2AMAPK1 | |
| SCHEMBL2278254 | 0.73 | PPARG (0.48) | ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268611-A2 | AMINOALKYLPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009145989-A2 | AMINOALKYLPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2009-12-03 | — | — | WO | disclosed |