Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 10/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1644659 | 0.91 | FAAH (0.45) | NAAAFAAHCCR5KDM4EALDH1A1 | |
| SCHEMBL1643063 | 0.83 | FAAH (0.47) | NAAAFAAHALDH1A1MEN1KMT2A | |
| SCHEMBL1643021 | 0.82 | FAAH (0.46) | NAAAFAAHKDM4EALDH1A1MEN1 | |
| SCHEMBL1644718 | 0.81 | FAAH (0.46) | NAAAFAAHALDH1A1MEN1KMT2A | |
| SCHEMBL1644793 | 0.81 | CCR5 (0.42) | PTGER1CCR5KDM4EALDH1A1MEN1 | |
| SCHEMBL13760930 | 0.80 | FAAH (0.45) | NAAAFAAHKDM4EALDH1A1MEN1 | |
| SCHEMBL1643553 | 0.80 | ALDH1A1 (0.42) | CCR5KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL1643771 | 0.80 | FAAH (0.50) | NAAAFAAHALDH1A1MEN1KMT2A | |
| SCHEMBL1643520 | 0.79 | FAAH (0.51) | NAAAFAAHKDM4EALDH1A1MEN1 | |
| SCHEMBL1010847 | 0.76 | ALDH1A1 (0.47) | CCR5KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257536-A2 | CYCLIC DIARYL ETHER AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009102893-A2 | CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 receptors | AMIRA PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |