Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1350345 | 0.82 | ALDH1A1 (0.46) | THRBALDH1A1SMN1; SMN2ALOX15LMNA | |
| SCHEMBL12237083 | 0.82 | ALDH1A1 (0.46) | THRBALDH1A1SMN1; SMN2ALOX15LMNA | |
| SCHEMBL2801704 | 0.73 | — | — | |
| SCHEMBL3089364 | 0.73 | — | — | |
| SCHEMBL3089367 | 0.73 | — | — | |
| SCHEMBL464624 | 0.71 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2ALOX15LMNAHPGD | |
| SCHEMBL10020569 | 0.68 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2ALOX15LMNAHPGD | |
| SCHEMBL13267564 | 0.68 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL24328680 | 0.67 | ALDH1A1 (0.42) | THRBALDH1A1SMN1; SMN2ALOX15LMNA | |
| SCHEMBL17040309 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024147972-A2 | DNA POLYMERASE THETA INHIBITORS CONTAINING NON-SATURATED 5-MEMBERED HETEROCYCLIC RINGS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-07-11 | — | — | WO | disclosed |