Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 9/20 | 0.72 |
| ▸ | CACNA1F | O60840 | 8/20 | 0.72 |
| ▸ | CACNA1D | Q01668 | 8/20 | 0.72 |
| ▸ | CACNA1S | Q13698 | 8/20 | 0.72 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.72 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.72 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.72 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.72 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.72 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.72 |
| ▸ | SCN1A | P35498 | 2/20 | 0.72 |
| ▸ | HTR2B | P41595 | 2/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.72 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.72 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.72 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.72 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.72 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10733629 | 0.89 | CACNA1F (0.76) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| Nisoldipine SCHEMBL1172989 | 0.84 | CACNA1C (1.00) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| Nisoldipine SCHEMBL19348996 | 0.84 | CACNA1C (1.00) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| Nisoldipine SCHEMBL29420725 | 0.84 | CACNA1C (1.00) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| Nisoldipine SCHEMBL39780 | 0.84 | CACNA1C (1.00) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| Nisoldipine SCHEMBL39779 | 0.84 | CACNA1C (1.00) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| Nisoldipine SCHEMBL3855961 | 0.83 | CACNA1C (0.98) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| Nisoldipine SCHEMBL919020 | 0.83 | CACNA1C (0.98) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| Nisoldipine SCHEMBL27608147 | 0.83 | CACNA1C (0.98) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL4608919 | 0.81 | CACNA1C (0.64) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101782-B2 | Drug hybrid of rivastigmine or physostigmine with tranylcypromine, amoxapine, desipramine, nortriptyline, protriptyline, fluoxetine, fluvoxamine, paroxetine, duloxetine, betahistine, amlodipine, proylhexedrine, rimantadine, desloratadine; Alzheimer's disease; Parkinson's disease, impairment in memory | COLUCID PHARMACEUTICALS, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-20080261950-A1 | Compounds that inhibit cholinesterase | COLUCID PHARMACEUTICALS, INC. (US) | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261950-A1 | Compounds that inhibit cholinesterase | ACHE, BCHE, CHAT | CACNA1C 1277/4885CACNA1F 1591/4885CACNA1D 1322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.