SCHEMBL4608919

SCHEMBL4608919

CC1=C(C(=O)O)C(c2ccccc2[N+](=O)[O-])C(C(=O)OCC(C)C)=C(C)N1C

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1C Q13936 6/20 0.64
CACNA1F O60840 5/20 0.64
CACNA1D Q01668 5/20 0.64
CACNA1S Q13698 5/20 0.64
ADORA3 P0DMS8 3/20 0.64
ABCC4 O15439 2/20 0.64
ABCB11 O95342 2/20 0.64
LMNA P02545 2/20 0.64
CYP1A2 P05177 2/20 0.64
ADORA2A P29274 2/20 0.64
ADORA1 P30542 2/20 0.64
OPRM1 P35372 2/20 0.64
SCN1A P35498 2/20 0.64
HTR2B P41595 2/20 0.64
KCNH2 Q12809 2/20 0.64
SCN5A Q14524 2/20 0.64
SCN2A Q99250 2/20 0.64
SCN3A Q9NY46 2/20 0.64
NR1I2 O75469 1/20 0.64
NR3C1 P04150 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10733629 0.92 CACNA1F (0.76) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL11683170 0.85 TSHR (0.65) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL7432246 0.84 CACNA1C (0.84) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL9602040 0.82 CACNA1D (0.57) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL4608536 0.81 CACNA1D (0.92) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL10109201 0.81 CACNA1C (0.72) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL11748826 0.80 CACNA1B (0.52) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL11754347 0.80 TSHR (0.49) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL1672208 0.80 TSHR (0.70) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL4880853 0.79 ABCC4 (0.47) CACNA1CCACNA1FCACNA1DCACNA1SADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1532110-B1 INDUSTRIAL PROCESS FOR THE SYNTHESIS OF ISOBUTYL METHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINE DICARBOXYLATE (NISOLDIPINE) ERREGIERRE SPA (IT) 2008-07-23 EP claimed
US-20080095841-A1 Pharmaceutical Composition, Method for Producing the Same, and Method for Stabilizing Dihydropyridine Compound in the Pharmaceutical Composition EISAI R&D MANAGEMENT CO., LTD. (JP) 2008-04-24 US disclosed
EP-1813274-A1 MEDICINAL COMPOSITION, PROCESS FOR PRODUCING THE SAME, AND METHOD OF STABILIZING DIHYDROPYRIDINE COMPOUND IN MEDICINAL COMPOSITION Eisai R&D Management Co., Ltd. (JP) 2007-08-01 EP disclosed