Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.43 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TK1 | P04183 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20310514 | 1.00 | PNP (0.54) | PNPALDH1A1MAPTBLMPMP22 | |
| SCHEMBL13351290 | 1.00 | PNP (0.54) | PNPALDH1A1MAPTBLMPMP22 | |
| SCHEMBL13318964 | 1.00 | PNP (0.54) | PNPALDH1A1MAPTBLMPMP22 | |
| SCHEMBL657360 | 1.00 | PNP (0.54) | PNPALDH1A1MAPTBLMPMP22 | |
| SCHEMBL14543297 | 1.00 | PNP (0.54) | PNPALDH1A1MAPTBLMPMP22 | |
| SCHEMBL657361 | 1.00 | PNP (0.54) | PNPALDH1A1MAPTBLMPMP22 | |
| SCHEMBL1401218 | 0.96 | PNP (0.51) | PNPALDH1A1MAPTBLMPMP22 | |
| SCHEMBL7047708 | 0.91 | ADORA3 (0.54) | PNPALDH1A1MAPTBLMPMP22 | |
| SCHEMBL655857 | 0.89 | PNP (0.65) | PNPMAPTCYP3A4ADRB1DNMT1 | |
| SCHEMBL655858 | 0.89 | PNP (0.65) | PNPMAPTCYP3A4ADRB1DNMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095077-A1 | METHODS AND COMPOSITIONS RELATED TO MODIFIED GUANINE BASES FOR CONTROLLING OFF-TARGET EFFECTS IN RNA INTERFERENCE | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2012-04-19 | — | — | US | disclosed |
| US-20120095077-A1 | METHODS AND COMPOSITIONS RELATED TO MODIFIED GUANINE BASES FOR CONTROLLING OFF-TARGET EFFECTS IN RNA INTERFERENCE | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2012-04-19 | — | — | US | disclosed |
| WO-2010111290-A1 | METHODS AND COMPOSITIONS RELATED TO MODIFIED GUANINE BASES FOR CONTROLLING OFF-TARGET EFFECTS IN RNA INTERFERENCE | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2010-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095077-A1 | METHODS AND COMPOSITIONS RELATED TO MODIFIED GUANINE BASES FOR CONTROLLING OFF-TARGET EFFECTS IN RNA INTERFERENCE | NSUN2, RNMT, NSUN3 | PNP 309/4885ALDH1A1 4274/4885MAPT 4672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.