Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 5/20 | 0.40 |
| ▸ | JAK1 | P23458 | 5/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 3/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL820247 | 1.00 | MET (0.45) | METPOLBTGM2DRD4DRD2 | |
| SCHEMBL820242 | 1.00 | MET (0.45) | METPOLBTGM2DRD4DRD2 | |
| SCHEMBL374971 | 1.00 | MET (0.45) | METPOLBTGM2DRD4DRD2 | |
| SCHEMBL818205 | 0.87 | MET (0.41) | METPOLBTGM2DRD4DRD2 | |
| SCHEMBL820249 | 0.87 | MET (0.41) | METPOLBTGM2DRD4DRD2 | |
| SCHEMBL820255 | 0.84 | DRD2 (0.46) | METTGM2DRD4DRD2DRD3 | |
| SCHEMBL27821707 | 0.84 | DRD2 (0.46) | METTGM2DRD4DRD2DRD3 | |
| SCHEMBL379870 | 0.80 | BCHE (0.39) | METPOLBTGM2 | |
| SCHEMBL13787023 | 0.80 | BCHE (0.39) | METPOLBTGM2 | |
| SCHEMBL820248 | 0.80 | BCHE (0.39) | METPOLBTGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2409984-A1 | Dimeric IAP Antagonists | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2012-01-25 | — | — | EP | disclosed |
| WO-2009094287-A1 | IAP INHIBITORS | TETRALOGIC PHARMACEUTICAL CORPORATION (US) | 2009-07-30 | — | — | WO | disclosed |