⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12462284 | 0.77 | NOS3 (0.35) | — | |
| SCHEMBL13523667 | 0.73 | TP53 (0.32) | — | |
| SCHEMBL25444289 | 0.73 | HTR5A (0.34) | — | |
| SCHEMBL30681558 | 0.67 | — | — | |
| SCHEMBL18931204 | 0.67 | — | — | |
| SCHEMBL28816039 | 0.67 | MEN1 (0.32) | — | |
| SCHEMBL10750799 | 0.66 | ALDH1A1 (0.36) | — | |
| SCHEMBL6633592 | 0.66 | NPSR1 (0.35) | — | |
| SCHEMBL19675348 | 0.65 | ALDH1A1 (0.32) | — | |
| SCHEMBL18434928 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250122149-A1 | KETAMINE DERIVATIVES AND COMPOSITIONS THEREOF | XWPharma Ltd. (KY) | 2025-04-17 | — | — | US | disclosed |
| US-12209060-B2 | Ketamine derivatives and compositions thereof | XWPharma Ltd. (KY) | 2025-01-28 | — | — | US | disclosed |
| US-20220411365-A1 | KETAMINE DERIVATIVES AND COMPOSITIONS THEREOF | XWPharma Ltd. (KY) | 2022-12-29 | — | — | US | disclosed |
| US-11440874-B2 | Ketamine derivatives and compositions thereof | XWPharma Ltd. (KY) | 2022-09-13 | — | — | US | disclosed |
| CN-112135812-B | Ketamine derivatives and pharmaceutical compositions thereof | 凯瑞康宁生物工程（武汉）有限公司 | 2022-01-18 | — | — | CN | disclosed |
| US-20210393557-A1 | Regulators of the Endoplasmic Reticulum Proteostasis Network | THE SCRIPPS RESEARCH INSTITUTE | 2021-12-23 | — | — | US | disclosed |
| EP-3908571-A1 | KETAMINE DERIVATIVES AND COMPOSITIONS THEREOF | XWPharma Ltd. (KY) | 2021-11-17 | — | — | EP | disclosed |
| US-11135186-B2 | Regulators of the endoplasmic reticulum proteostasis network | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-10-05 | — | — | US | disclosed |
| US-20210032199-A1 | KETAMINE DERIVATIVES AND COMPOSITIONS THEREOF | XW LABORATORIES INC. (KY) | 2021-02-04 | — | — | US | disclosed |
| CN-112135812-A | Ketamine derivatives and pharmaceutical compositions thereof | 凯瑞康宁生物工程（武汉）有限公司 | 2020-12-25 | — | — | CN | disclosed |
| US-10836714-B2 | Ketamine derivatives and compositions thereof | XW LABORATORIES INC. (KY) | 2020-11-17 | — | — | US | disclosed |
| US-20200231540-A1 | KETAMINE DERIVATIVES AND COMPOSITIONS THEREOF | XW LABORATORIES INC. (KY) | 2020-07-23 | — | — | US | disclosed |
| WO-2020143198-A1 | KETAMINE DERIVATIVES AND COMPOSITIONS THEREOF | XW LABORATORIES INC. (KY) | 2020-07-16 | — | — | WO | disclosed |
| US-10683262-B2 | Ketamine derivatives and compositions thereof | XW LABORATORIES INC. (KY) | 2020-06-16 | — | — | US | disclosed |
| US-20190322618-A1 | KETAMINE DERIVATIVES AND COMPOSITIONS THEREOF | XWPharma Ltd. (KY) | 2019-10-24 | — | — | US | disclosed |
| CN-107200705-A | A kind of preparation method of the indolone derivatives of 3 nitro 2 | 宁波大学 | 2017-09-26 | — | — | CN | disclosed |
| US-20120165335-A1 | CDK INHIBITORS | CURIS, INC. | 2012-06-28 | — | — | US | disclosed |