Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.32 |
| ▸ | LCAT | P04180 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10112533 | 1.00 | HSD11B1 (0.35) | HSD11B1TYK2HCRTR2HCRTR1FFAR4 | |
| SCHEMBL4570188 | 0.91 | HSD11B1 (0.35) | HSD11B1TYK2HCRTR2HCRTR1HTR7 | |
| SCHEMBL5630252 | 0.80 | HSD11B1 (0.47) | HSD11B1HCRTR2HCRTR1HTR7LCAT | |
| SCHEMBL4719611 | 0.80 | FFAR4 (0.53) | HCRTR2HCRTR1FFAR4KCNH2LCAT | |
| SCHEMBL4721294 | 0.80 | FFAR4 (0.53) | HCRTR2HCRTR1FFAR4KCNH2LCAT | |
| SCHEMBL5630431 | 0.80 | FFAR4 (0.53) | HCRTR2HCRTR1FFAR4KCNH2LCAT | |
| SCHEMBL4723036 | 0.80 | HSD11B1 (0.47) | HSD11B1HCRTR2HCRTR1HTR7LCAT | |
| SCHEMBL4790365 | 0.80 | HSD11B1 (0.47) | HSD11B1HCRTR2HCRTR1HTR7LCAT | |
| SCHEMBL10112730 | 0.78 | HSD11B1 (0.38) | HSD11B1FFAR4 | |
| SCHEMBL4722855 | 0.77 | HCRTR2 (0.47) | HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193207-B2 | Lactam compounds and methods of using the same | INCYTE CORPORATION (US) | 2012-06-05 | — | — | US | disclosed |
| US-20070129345-A1 | Lactam compounds and methods of using the same | INCYTE CORPORATION | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129345-A1 | Lactam compounds and methods of using the same | HSD11B1, HSD17B11, HSD17B1 | HSD11B1 1/4885TYK2 4860/4885HCRTR2 4496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.