Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.47 |
| ▸ | LCAT | P04180 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 7/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.40 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4723036 | 1.00 | HSD11B1 (0.47) | HSD11B1LCATHTR7HRH3MALT1 | |
| SCHEMBL4790365 | 1.00 | HSD11B1 (0.47) | HSD11B1LCATHTR7HRH3MALT1 | |
| SCHEMBL550934 | 0.91 | HSD11B1 (0.46) | HSD11B1LCATHTR7HRH3MALT1 | |
| SCHEMBL2699428 | 0.91 | HSD11B1 (0.46) | HSD11B1LCATHTR7HRH3MALT1 | |
| SCHEMBL2699962 | 0.91 | HSD11B1 (0.46) | HSD11B1LCATHTR7HRH3MALT1 | |
| SCHEMBL549724 | 0.91 | HSD11B1 (0.46) | HSD11B1LCATHTR7HRH3MALT1 | |
| SCHEMBL551416 | 0.91 | HSD11B1 (0.46) | HSD11B1LCATHTR7HRH3MALT1 | |
| SCHEMBL548641 | 0.91 | HSD11B1 (0.46) | HSD11B1LCATHTR7HRH3MALT1 | |
| SCHEMBL548640 | 0.91 | HSD11B1 (0.46) | HSD11B1LCATHTR7HRH3MALT1 | |
| SCHEMBL2699432 | 0.91 | HSD11B1 (0.46) | HSD11B1LCATHTR7HRH3MALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193207-B2 | Lactam compounds and methods of using the same | INCYTE CORPORATION (US) | 2012-06-05 | — | — | US | claimed |
| US-20070129345-A1 | Lactam compounds and methods of using the same | INCYTE CORPORATION | 2007-06-07 | — | — | US | claimed |
| US-8193207-B2 | Lactam compounds and methods of using the same | INCYTE CORPORATION (US) | 2012-06-05 | — | — | US | disclosed |
| US-20070129345-A1 | Lactam compounds and methods of using the same | INCYTE CORPORATION | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129345-A1 | Lactam compounds and methods of using the same | HSD11B1, HSD17B11, HSD17B1 | HSD11B1 1/4885LCAT 268/4885HTR7 4367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.