Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 17/20 | 1.00 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.67 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.67 |
| ▸ | MMP1 | P03956 | 1/20 | 0.67 |
| ▸ | MMP2 | P08253 | 1/20 | 0.67 |
| ▸ | MMP3 | P08254 | 1/20 | 0.67 |
| ▸ | MMP9 | P14780 | 1/20 | 0.67 |
| ▸ | MMP13 | P45452 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10112706 | 0.87 | TNF (0.79) | TNFADAM17ADAM10MMP1MMP2 | |
| SCHEMBL13200542 | 0.86 | TNF (0.78) | TNFADAM17ADAM10MMP1MMP2 | |
| SCHEMBL10131164 | 0.86 | TNF (1.00) | TNFADAM17ADAM10MMP1MMP2 | |
| SCHEMBL10131186 | 0.85 | TNF (1.00) | TNFADAM17ADAM10MMP1MMP2 | |
| SCHEMBL13200426 | 0.85 | ADAM17 (0.81) | TNFADAM17ADAM10MMP1MMP2 | |
| SCHEMBL13200819 | 0.84 | ADAM17 (0.79) | TNFADAM17ADAM10MMP1MMP2 | |
| SCHEMBL13363181 | 0.84 | TNF (0.72) | TNFADAM17 | |
| SCHEMBL13200296 | 0.84 | TNF (0.79) | TNFADAM17ADAM10MMP1MMP2 | |
| SCHEMBL10131729 | 0.83 | TNF (1.00) | TNFADAM17ADAM10MMP1MMP2 | |
| SCHEMBL13200177 | 0.83 | ADAM17 (0.79) | TNFADAM17ADAM10MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8541572-B2 | Compounds for the treatment of inflammatory disorders | MERCK SHARP & DOHME CORP. (US) | 2013-09-24 | — | — | US | disclosed |
| US-8541572-B2 | Compounds for the treatment of inflammatory disorders | MERCK SHARP & DOHME CORP. (US) | 2013-09-24 | — | — | US | disclosed |
| US-20120010181-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | MERCK SHARP & DOHME CORP. | 2012-01-12 | — | — | US | disclosed |
| US-20120010181-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | MERCK SHARP & DOHME CORP. | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010181-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | TNF, ADAMTS1, ADAMTS7 | TNF 1/4885ADAM17 7/4885ADAM10 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.