Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 7/20 | 0.49 |
| ▸ | CNR2 | P34972 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.45 |
| ▸ | MARS1 | P56192 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1010431 | 0.88 | MARS1 (0.51) | CNR1CNR2MAPTCYP1A2CYP3A4 | |
| SCHEMBL1010395 | 0.79 | ALDH1A1 (0.53) | CNR1CNR2GAAMAPTPOLB | |
| SCHEMBL1011693 | 0.74 | ALDH1A1 (0.46) | CNR1CNR2GAAMAPTPOLB | |
| SCHEMBL1009792 | 0.73 | ALDH1A1 (0.44) | CNR1CNR2GAAMAPTPOLB | |
| SCHEMBL1011938 | 0.72 | MARS1 (0.41) | CNR1CNR2GAAMAPTPOLB | |
| SCHEMBL1009687 | 0.69 | CNR2 (0.87) | CNR1CNR2 | |
| SCHEMBL971707 | 0.68 | CNR1 (0.59) | CNR1CNR2 | |
| SCHEMBL12495024 | 0.68 | MAPT (0.59) | GAAMAPTPOLBTDP1L3MBTL1 | |
| SCHEMBL3819281 | 0.67 | MARS1 (0.54) | L3MBTL1CYP1A2MARS1PTGS1PTGS2 | |
| SCHEMBL971737 | 0.66 | PTGS2 (0.56) | CNR1L3MBTL1CYP1A2MARS1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094706-B1 | SUBSTITUTED 2,5-DFFLYDRO-3H-PYRAZOLO[4,3-C]PYRIDAZIN-3-ONE DERIVATIVES, PREPARATION THEREOF AND USE OF SAME AS CANNABINOID CB1 RECEPTOR LIGANDS | SANOFI AVENTIS (FR) | 2011-01-05 | — | — | EP | disclosed |