Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | NCF1 | P14598 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GPR3 | P46089 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6538649 | 0.72 | — | — | |
| SCHEMBL18929849 | 0.71 | MAPT (0.39) | MAPTALDH1A1HPGDGLAACHE | |
| SCHEMBL3936849 | 0.71 | MAP4K4 (0.30) | — | |
| SCHEMBL3929426 | 0.71 | KDM4E (0.31) | ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL400612 | 0.70 | MAPT (0.47) | MAPTALDH1A1HPGDGLAACHE | |
| SCHEMBL3938298 | 0.68 | ALDH1A1 (0.43) | MAPTALDH1A1KDM4ECYP1A2HSD17B10 | |
| SCHEMBL6345143 | 0.67 | LMNA (0.38) | MAPTALDH1A1KDM4ECYP1A2TDP1 | |
| SCHEMBL129037 | 0.67 | CYP2A6 (0.50) | MAPTALDH1A1HPGDGLAACHE | |
| SCHEMBL6700746 | 0.64 | MAPT (0.65) | MAPTALDH1A1HPGDGLAACHE | |
| SCHEMBL2910 | 0.63 | CYP1A2 (0.44) | MAPTALDH1A1HPGDGLAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2477 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240208992-A1 | MACROCYCLES AS CFTR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2024-06-27 | — | — | US | claimed |
| US-20240190883-A1 | KRAS PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2024-06-13 | — | — | US | claimed |
| US-20240174643-A1 | SOS1 PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2024-05-30 | — | — | US | claimed |
| CN-118076602-A | Heteroaryl-acetylenes, pharmaceutical compositions thereof and their therapeutic uses | 嘉兴优博生物技术有限公司 | 2024-05-24 | — | — | CN | claimed |
| EP-4355741-A1 | SOS1 PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | Biotheryx, Inc. (US) | 2024-04-24 | — | — | EP | claimed |
| WO-2024056798-A1 | MACROCYCLIC CFTR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2024-03-21 | — | — | WO | claimed |
| EP-4308575-A1 | MACROCYCLES AS CFTR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2024-01-24 | — | — | EP | claimed |
| CN-116981672-A | Macrocyclic compounds as CFTR modulators | 爱杜西亚药品有限公司 | 2023-10-31 | — | — | CN | claimed |
| CN-111465596-B | Pyridinium salt and pest control agent | 日本曹达株式会社 | 2023-09-22 | — | — | CN | claimed |
| CN-115745898-A | Aromatic acrylamide-triazole compound, and preparation method and application thereof | 许昌学院 | 2023-03-07 | — | — | CN | claimed |
| CN-1489601-A | Multinuclear metallocene catalyst | ������ѧ��ʽ���� | 2004-04-14 | — | — | CN | claimed |
| US-20030008797-A1 | Ligand and complex for catalytically bleaching a substrate | UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. | 2003-01-09 | — | — | US | claimed |
| WO-2002077147-A1 | LIGAND AND COMPLEX FOR CATALYTICALLY BLEACHING A SUBSTRATE | UNILEVER PLC (GB) | 2002-10-03 | — | — | WO | claimed |
| US-20020135292-A1 | Electroconductive device, organic electroluminescence device using the device and process for producing the electroconductive device | CANON KABUSHIKI KAISHA (JP) | 2002-09-26 | — | — | US | claimed |
| EP-1227084-A1 | DRUG DISCHARGE PUMP INHIBITORS | Microcide Pharmaceuticals, Inc. (US) | 2002-07-31 | — | — | EP | claimed |
| US-5932363-A | LUMINESCENT COMPOSITION COMPRISED OF MIXTURE OF FLUORESCENT DYE AND SPECIFIED METAL CHELATE COMPOUND | XEROX CORPORATION (US) | 1999-08-03 | — | — | US | claimed |
| US-5648448-A | Method of preparation of polyquinolines | HITACHI CHEMICAL COMPANY, LTD. (JP) | 1997-07-15 | — | — | US | claimed |
| US-5374416-A | Nitrogenous macrocyclic ligands, polymetallic complexes and diagnostic and therapeutic composition | GUERBET S.A. (FR) | 1994-12-20 | — | — | US | claimed |
| US-5367038-A | Polyisoquinolinediyls and uses thereof | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 1994-11-22 | — | — | US | claimed |
| US-5081245-A | Selective antitumor agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-01-14 | — | — | US | claimed |