Sugi Predict

Sugi Predict / Compounds / SCHEMBL10115532

SCHEMBL10115532

SCHEMBL10115532

CCc1ccc(NC(=O)N2CCC(NS(=O)(=O)C(C)(C)C)CC2)cc1

nearest known ligand 0.57

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 4/20 0.57
▸ RAB9A P51151 3/20 0.57
▸ KMT2A Q03164 3/20 0.57
▸ MAPT P10636 4/20 0.54
▸ TP53 P04637 1/20 0.54
▸ STAT1 P42224 1/20 0.53
▸ SMN1; SMN2 Q16637 1/20 0.53
▸ CNR2 P34972 1/20 0.53
▸ EPHX2 P34913 2/20 0.52
▸ ALDH1A1 P00352 1/20 0.52
▸ LMNA P02545 2/20 0.50
▸ NPSR1 Q6W5P4 2/20 0.50
▸ FAAH O00519 1/20 0.48
▸ MEN1 O00255 2/20 0.47
▸ POLB P06746 1/20 0.47
▸ GAA P10253 1/20 0.47
▸ TSHR P16473 1/20 0.47
▸ ATM Q13315 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10115574 0.91 LMNA (0.48) NPC1RAB9AKMT2AMAPTTP53
SCHEMBL597459 0.89 CNR2 (0.56) NPC1RAB9AKMT2AMAPTTP53
SCHEMBL10115614 0.87 LMNA (0.51) KMT2ACNR2EPHX2ALDH1A1LMNA
SCHEMBL10115617 0.87 LMNA (0.53) KMT2AMAPTTP53CNR2EPHX2
SCHEMBL10115527 0.87 LMNA (0.66) NPC1RAB9AKMT2AMAPTLMNA
SCHEMBL12882021 0.87 LMNA (0.53) KMT2ACNR2EPHX2ALDH1A1LMNA
SCHEMBL10115644 0.86 GLA (0.48) RAB9ASMN1; SMN2ALDH1A1LMNANPSR1
SCHEMBL10114621 0.86 KMT2A (0.59) NPC1RAB9AKMT2AMAPTSMN1; SMN2
SCHEMBL10115581 0.86 CNR2 (0.56) MAPTCNR2EPHX2ALDH1A1LMNA
SCHEMBL10115550 0.86 ALOX5 (0.56) NPC1RAB9AKMT2AMAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 — — US disclosed
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 — — US disclosed
US-20110039802-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2011-02-17 — — US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 — — US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 — — US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 — — US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 — — US disclosed
US-7265130-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2007-09-04 — — US disclosed
US-7265130-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2007-09-04 — — US disclosed
US-20070015762-A1 NPY Y5 antagonist KAWANISHI YASUYUKI 2007-01-18 — — US disclosed
US-20070015762-A1 NPY Y5 antagonist KAWANISHI YASUYUKI 2007-01-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070015762-A1 NPY Y5 antagonist NPY5R, NPY1R, NPY2R NPC1 1435/4885RAB9A 3699/4885KMT2A 2912/4885
US-20100292500-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R NPC1 1353/4885RAB9A 3651/4885KMT2A 2768/4885
US-20110039802-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R NPC1 1462/4885RAB9A 3820/4885KMT2A 2953/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.