Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.48 |
| ▸ | CCR8 | P51685 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10115574 | 0.94 | LMNA (0.48) | CNR2LMNANPSR1NPC1RAB9A | |
| SCHEMBL10115532 | 0.89 | NPC1 (0.57) | CNR2POLBLMNANPSR1NPC1 | |
| SCHEMBL10115527 | 0.83 | LMNA (0.66) | POLBLMNANPSR1NPC1RAB9A | |
| SCHEMBL12882021 | 0.83 | LMNA (0.53) | CNR2POLBLMNACCR8NPSR1 | |
| SCHEMBL10115617 | 0.83 | LMNA (0.53) | CNR2POLBLMNACCR8NPSR1 | |
| SCHEMBL10113010 | 0.83 | POLB (0.61) | POLBLMNANPY5RNPSR1NPC1 | |
| SCHEMBL12864650 | 0.83 | POLB (0.61) | POLBLMNANPY5RNPSR1NPC1 | |
| SCHEMBL10113036 | 0.83 | POLB (0.61) | POLBLMNANPY5RNPSR1NPC1 | |
| SCHEMBL10115644 | 0.82 | GLA (0.48) | POLBLMNANPSR1RAB9ASMN1; SMN2 | |
| SCHEMBL10115550 | 0.82 | ALOX5 (0.56) | CNR2LMNANPSR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8115027-B2 | NPY Y5 antagonist | SHIONOGI & CO., LTD. (JP) | 2012-02-14 | — | — | US | disclosed |
| US-8115027-B2 | NPY Y5 antagonist | SHIONOGI & CO., LTD. (JP) | 2012-02-14 | — | — | US | disclosed |
| US-8115027-B2 | NPY Y5 antagonist | SHIONOGI & CO., LTD. (JP) | 2012-02-14 | — | — | US | disclosed |
| US-20110039802-A1 | NPY Y5 ANTAGONIST | KAWANISHI YASUYUKI | 2011-02-17 | — | — | US | disclosed |
| US-20110039802-A1 | NPY Y5 ANTAGONIST | KAWANISHI YASUYUKI | 2011-02-17 | — | — | US | disclosed |
| US-20110039802-A1 | NPY Y5 ANTAGONIST | KAWANISHI YASUYUKI | 2011-02-17 | — | — | US | disclosed |
| US-20100292500-A1 | NPY Y5 ANTAGONIST | KAWANISHI YASUYUKI | 2010-11-18 | — | — | US | disclosed |
| US-20100292500-A1 | NPY Y5 ANTAGONIST | KAWANISHI YASUYUKI | 2010-11-18 | — | — | US | disclosed |
| US-20100292500-A1 | NPY Y5 ANTAGONIST | KAWANISHI YASUYUKI | 2010-11-18 | — | — | US | disclosed |
| US-7781461-B2 | NPY Y5 antagonist | KAWANISHI YASUYUKI | 2010-08-24 | — | — | US | disclosed |
| EP-1249233-B1 | NPYY5 ANTAGONISTS | SHIONOGI & CO (JP) | 2008-08-20 | — | — | EP | disclosed |
| US-7265130-B2 | NPY Y5 antagonist | SHIONOGI & CO., LTD. (JP) | 2007-09-04 | — | — | US | disclosed |
| US-7265130-B2 | NPY Y5 antagonist | SHIONOGI & CO., LTD. (JP) | 2007-09-04 | — | — | US | disclosed |
| US-7265130-B2 | NPY Y5 antagonist | SHIONOGI & CO., LTD. (JP) | 2007-09-04 | — | — | US | disclosed |
| US-20070015762-A1 | NPY Y5 antagonist | KAWANISHI YASUYUKI | 2007-01-18 | — | — | US | disclosed |
| US-20070015762-A1 | NPY Y5 antagonist | KAWANISHI YASUYUKI | 2007-01-18 | — | — | US | disclosed |
| US-20040180964-A1 | NPY Y5 antagonist | SHIONOGI & CO. | 2004-09-16 | — | — | US | disclosed |
| US-20040176462-A1 | NPY Y5 antagonist | SHIONOGI & CO., LTD. | 2004-09-09 | — | — | US | disclosed |
| US-6699891-B1 | SULFONAMIDE OR SULFINAMIDE DERIVATIVES; NEUROPEPTIDE Y ANTAGONISTS; ANOREXIGENIC OR ANTIOBESITY AGENTS | SHIONOGI & CO., LTD. (JP) | 2004-03-02 | — | — | US | disclosed |
| EP-1249233-A1 | NPYY5 ANTAGONISTS | SHIONOGI & CO., LTD. (JP) | 2002-10-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176462-A1 | NPY Y5 antagonist | NPY5R, NPY1R, NPY2R | CNR2 31/4885POLB 4674/4885LMNA 2375/4885 |
| US-20070015762-A1 | NPY Y5 antagonist | NPY5R, NPY1R, NPY2R | CNR2 29/4885POLB 4727/4885LMNA 1925/4885 |
| US-20100292500-A1 | NPY Y5 ANTAGONIST | NPY5R, NPY1R, NPY2R | CNR2 30/4885POLB 4751/4885LMNA 2068/4885 |
| US-20110039802-A1 | NPY Y5 ANTAGONIST | NPY5R, NPY1R, NPY2R | CNR2 29/4885POLB 4721/4885LMNA 1857/4885 |
| US-20040180964-A1 | NPY Y5 antagonist | NPY5R, NPY1R, NPY2R | CNR2 31/4885POLB 4674/4885LMNA 2375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.