Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | LATS1 | O95835 | 4/20 | 0.39 |
| ▸ | LATS2 | Q9NRM7 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | AOC1 | P19801 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20940108 | 1.00 | RPS6KA3 (0.41) | RPS6KA3LOXL2LATS1LATS2TSHR | |
| SCHEMBL14612403 | 1.00 | RPS6KA3 (0.41) | RPS6KA3LOXL2LATS1LATS2TSHR | |
| SCHEMBL21783997 | 0.85 | RPS6KA3 (0.40) | RPS6KA3LOXL2LATS1LATS2SMN1; SMN2 | |
| SCHEMBL10264269 | 0.82 | LOXL2 (0.42) | RPS6KA3LOXL2LATS1LATS2CYP17A1 | |
| SCHEMBL20940090 | 0.80 | RPS6KA3 (0.36) | RPS6KA3LOXL2LATS1LATS2 | |
| SCHEMBL83998 | 0.79 | RPS6KA3 (0.54) | RPS6KA3LOXL2LATS1LATS2AOC1 | |
| SCHEMBL24271130 | 0.79 | LOXL2 (0.44) | RPS6KA3LOXL2LATS1LATS2 | |
| SCHEMBL13385945 | 0.79 | PDE2A (0.47) | RPS6KA3LOXL2LATS1LATS2TP53 | |
| SCHEMBL25493980 | 0.79 | TSHR (0.41) | RPS6KA3TSHRHTTRAB9ANPC1 | |
| SCHEMBL13848825 | 0.78 | TSHR (0.39) | RPS6KA3LATS1LATS2TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021074-A1 | P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120021074-A1 | P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | P2RX3, P2RX1, P2RX2 | RPS6KA3 1373/4885LOXL2 2241/4885LATS1 4417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.